CAS 944261-79-4|A-803467

Introduction：Basic information about CAS 944261-79-4|A-803467, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. A-803467 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles4
7. Synonyms

Common Name	A-803467
CAS Number	944261-79-4	Molecular Weight	357.788
Density	1.3±0.1 g/cm3	Boiling Point	450.6±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₁₆ClNO₄	Melting Point	128-130?C
MSDS	ChineseUSA	Flash Point	226.3±28.7 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
Synonym	More Synonyms

A-803467 BiologicalActivity

Description	A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nMTarget: Nav1.8 sodium channelA 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological Disease
References	[1]. McGaraughty, et al. A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide)], attenuates spinal neuronal activity in neuropathic rats. Journal of Pharmacology and Experimental Therapeutics (2008), [2]. Jarvis MF, et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8520-5. [3]. Joshi SK, et al. Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models. http://www.ncbi.nlm.nih.gov/pubmed/19070548 [4]. Kort ME, et al. Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5.

Description

A 803467 is a selective Nav1.8 sodium channel blocker with an IC50 of 8 nM; over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7. IC50 value: 8 nMTarget: Nav1.8 sodium channelA 803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Neurological Disease

References

[1]. McGaraughty, et al. A selective NaV1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide)], attenuates spinal neuronal activity in neuropathic rats. Journal of Pharmacology and Experimental Therapeutics (2008),

[2]. Jarvis MF, et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8520-5.

[3]. Joshi SK, et al. Additive antinociceptive effects of the selective Nav1.8 blocker A-803467 and selective TRPV1 antagonists in rat inflammatory and neuropathic pain models. http://www.ncbi.nlm.nih.gov/pubmed/19070548

[4]. Kort ME, et al. Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6812-5.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	450.6±45.0 °C at 760 mmHg
Melting Point	128-130?C
Molecular Formula	C₁₉H₁₆ClNO₄
Molecular Weight	357.788
Flash Point	226.3±28.7 °C
Exact Mass	357.076782
PSA	60.70000
LogP	4.93
Appearance of Characters	white to tan
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.611
InChIKey	VHKBTPQDHDSBSP-UHFFFAOYSA-N
SMILES	COc1cc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc(OC)c1
Storage condition	Store at +4°C
Water Solubility	DMSO: >10mg/mL

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	R22
RIDADR	NONH for all modes of transport
HS Code	2932190090

Customs

HS Code	2932190090
Summary	2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles4

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

Proc. Natl. Acad. Sci. U. S. A. 104 , 8520-5, (2007)

Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed against Na(v)1.8 have shown that this channel...

Painful research: identification of a small-molecule inhibitor that selectively targets Nav1.8 sodium channels.

Mol. Interv. 7 , 192-5, (2007)

Voltage-gated sodium channels in nociceptive neurons are attractive targets for novel pain therapeutics. Although drugs that target voltage-gated sodium channels have proven value as pain therapeutics...

Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.

Circ. Res. 111 , 333-43, (2012)

The SCN10A gene encodes the neuronal sodium channel isoform Na(V)1.8. Several recent genome-wide association studies have linked SCN10A to PR interval and QRS duration, strongly suggesting an as-yet u...

Synonyms

5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide

2-Furancarboxamide, 5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)-

cc-433

A-803467

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