CAS 4546-39-8|Piperilate
Introduction：Basic information about CAS 4546-39-8|Piperilate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Piperilate | ||
|---|---|---|---|
| CAS Number | 4546-39-8 | Molecular Weight | 339.42800 |
| Density | 1.155 g/cm3 | Boiling Point | 444.1ºC at 760mmHg |
| Molecular Formula | C21H25NO3 | Melting Point | / |
| MSDS | / | Flash Point | 222.4ºC |
Names
| Name | 2-piperidin-1-ylethyl 2-hydroxy-2,2-diphenylacetate |
|---|---|
| Synonym | More Synonyms |
Piperilate BiologicalActivity
| Description | Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Neuronal Signaling >>AChE |
| In Vivo | Piperilate (11.3 mg/kg, 29.42 mg/kg; i.p.; single dose) shows anticholinergic activity, and (30 mg/kg; i.p.; single dose) exerts efficacy in mice poisoned by the organophosphates[1]. Piperilate (1 mg/kg; i.v.) causes hypotension in rabbit which is not blocked by dichloroisoproterenol or Atropine (HY-B1205)[2]. Piperilate (3 mg/kg; i.v.) decreases respiration and heart rate of test rabbits, blocks the Adrenaline (HY-122304)-induced constriction of an isolated rabbit auricle preparation[2]. Animal Model: Male albino mice (18-22 g)[1] Dosage: 11.3 mg/kg, 29.42 mg/kg Administration: Intraperitoneal injection; single dose Result: Showed anticholinergic activity with EC50 values of 11.33 mg/kg (antagonism of oxotremorine induced salivation) and 29.42 mg/kg (antagonism of oxotremorine induced tremor) in mice. |
Chemical & Physical Properties
| Density | 1.155 g/cm3 |
|---|---|
| Boiling Point | 444.1ºC at 760mmHg |
| Molecular Formula | C21H25NO3 |
| Molecular Weight | 339.42800 |
| Flash Point | 222.4ºC |
| Exact Mass | 339.18300 |
| PSA | 49.77000 |
| LogP | 2.88950 |
| Index of Refraction | 1.574 |
| InChIKey | RZWPJFMNFATBEG-UHFFFAOYSA-N |
| SMILES | O=C(OCCN1CCCCC1)C(O)(c1ccccc1)c1ccccc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 510 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 145 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 162 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 65,326,1969
Safety Information
| HS Code | 2933399090 |
|---|
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| Pipethanatum [INN-Latin] |
| 2-(1-Piperidino)ethyl benzilate |
| Pipetanato [INN-Spanish] |
| Piperilate |
| Benzilsaeure-(2-piperidino-aethylester) |
| pipethanate |
| BENZILIC ACID,2-PIPERIDINOETHYL ESTER |
| Benzilsaeure-<2-piperidino-ethylester> |
| 1-Piperidineethanol benzilate |
