Introduction：Basic information about CAS 3386-18-3|nonaethylene glycol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | nonaethylene glycol |
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| CAS Number | 3386-18-3 | Molecular Weight | 414.488 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 506.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C18H38O10 | Melting Point | / |
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| MSDS | / | Flash Point | 260.0±28.7 °C |
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Names
| Name | nonaethylene glycol |
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| Synonym | More Synonyms |
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nonaethylene glycol BiologicalActivity
| Description | Nonaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 506.2±45.0 °C at 760 mmHg |
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| Molecular Formula | C18H38O10 |
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| Molecular Weight | 414.488 |
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| Flash Point | 260.0±28.7 °C |
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| Exact Mass | 414.246490 |
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| PSA | 114.30000 |
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| LogP | -4.02 |
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| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
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| Index of Refraction | 1.464 |
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| InChIKey | YZUUTMGDONTGTN-UHFFFAOYSA-N |
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| SMILES | OCCOCCOCCOCCOCCOCCOCCOCCOCCO |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- RA5400000
- CHEMICAL NAME :
- Nonaethylene glycol
- CAS REGISTRY NUMBER :
- 3386-18-3
- BEILSTEIN REFERENCE NO. :
- 1804294
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C18-H38-O10
- MOLECULAR WEIGHT :
- 414.56
- WISWESSER LINE NOTATION :
- Q2/O2/ 8Q
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- Volume(issue)/page/year: 29,1363,1946 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,259,1941
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Safety Information
| RTECS | RA5400000 |
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| HS Code | 2909499000 |
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Customs
| HS Code | 2909499000 |
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| Summary | 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
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Synonyms
| polyethylene glycol |
| 3,6,9,12,15,18,21,24-Octaoxahexacosane-1,26-diol |
| EINECS 222-206-1 |
| nonaneethylene glycol |
| 2PE |
| 1icj |
| 2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol |
