CAS 18449-41-7|Madecassic acid
Introduction：Basic information about CAS 18449-41-7|Madecassic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Madecassic acid | ||
|---|---|---|---|
| CAS Number | 18449-41-7 | Molecular Weight | 504.698 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 641.7±55.0 °C at 760 mmHg |
| Molecular Formula | C30H48O6 | Melting Point | 270ºC (dec.) |
| MSDS | / | Flash Point | 355.9±28.0 °C |
Names
| Name | madecassic acid |
|---|---|
| Synonym | More Synonyms |
Madecassic acid BiologicalActivity
| Description | Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Interleukin RelatedSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX |
| Target | COX-2 TNF-α IL-1β IL-6 |
| References | [1]. Won JH, et al. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaBpathway in LPS-induced RAW 264.7 macrophage cells. Planta Med. 2010 Feb;76(3):251-7. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 641.7±55.0 °C at 760 mmHg |
| Melting Point | 270ºC (dec.) |
| Molecular Formula | C30H48O6 |
| Molecular Weight | 504.698 |
| Flash Point | 355.9±28.0 °C |
| Exact Mass | 504.345093 |
| PSA | 118.22000 |
| LogP | 4.99 |
| Vapour Pressure | 0.0±4.3 mmHg at 25°C |
| Index of Refraction | 1.591 |
| InChIKey | PRAUVHZJPXOEIF-AOLYGAPISA-N |
| SMILES | CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC43C)C2C1C |
| Storage condition | 2-8°C |
Safety Information
| Hazard Codes | Xi |
|---|---|
| Safety Phrases | 24/25 |
Synonyms
| Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2α,3β,5ξ,6β,9ξ,18ξ)- |
| Brahmanic acid |
| (2α,3β,5ξ,6β,9ξ,18ξ)-2,3,6,23-Tetrahydroxyurs-12-en-28-oic acid |
| 6-Hydroxyasiatic acid |
| 6BETA-HYDROXYASIATIC ACID |
| madecaic acid |
| (2α,3β,6β)-2,3,6,23-Tetrahydroxyurs-12-en-28-oic acid |
| madesica acid |
| MADESIC ACID |
| Urs-12-en-28-oic acid, 2,3,6,23-tetrahydroxy-, (2α,3β,6β)- |
| Madecassicacid |
| Brahmsaeure |
| (1S,2R,4aS,6aS,6bR,8R,8aR,9R,10R,11R,12aR,12bR,14bS)-8,10,11-Trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydro-4a(2H)-picenecarboxylic acid |
| Hydroxy asiaticoside |
| Brahmic acid |
