CAS 22611-34-3|Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)- (9CI)

Introduction：Basic information about CAS 22611-34-3|Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)- (9CI), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)- (9CI)
CAS Number	22611-34-3	Molecular Weight	378.42
Density	1.45g/cm3	Boiling Point	626.1ºC at 760mmHg
Molecular Formula	C₂₀H₂₆O₇	Melting Point	/
MSDS	/	Flash Point	224.9ºC

Names

Name	chaparrinone
Synonym	More Synonyms

BiologicalActivity

Description	Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC50: 0.037 and 0.34 μg/mL respectively)[1][2].
Related Catalog	Research Areas >>Infection
References	[1]. Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57(8):1205-8. [2]. François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28(4):635-40.

Description

Chaparrinone is a quassinoid that can be isolated from the root of Eurycoma harmandiana. Chaparrinone has antimalarial and cytotoxic activities against Plasmodium falciparum and P-388 cells (IC50: 0.037 and 0.34 μg/mL respectively)[1][2].

Related Catalog

Research Areas >>Infection

References

[1]. Kanchanapoom T, et al. Quassinoids from Eurycoma harmandiana. Phytochemistry. 2001 Aug;57(8):1205-8.

[2]. François G, et al. Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships. Int J Parasitol. 1998 Apr;28(4):635-40.

Chemical & Physical Properties

Density	1.45g/cm3
Boiling Point	626.1ºC at 760mmHg
Molecular Formula	C₂₀H₂₆O₇
Molecular Weight	378.42
Flash Point	224.9ºC
Exact Mass	378.16800
PSA	113.29000
LogP	0.16620
Vapour Pressure	2.67E-18mmHg at 25°C
Index of Refraction	1.627
InChIKey	VLYMLZRDCSQUQF-RZUZYEBMSA-N
SMILES	CC1=CC(=O)C(O)C2(C)C1CC1OC(=O)CC3C(C)C(O)C4(O)OCC13C42

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ7863800

CHEMICAL NAME :: Picras-3-ene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1-beta,11-beta,12-alpha)-

CAS REGISTRY NUMBER :: 22611-34-3

LAST UPDATED :: 199303

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C20-H26-O7

MOLECULAR WEIGHT :: 378.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 26,345,1991

Synonyms

Chaparvinon

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