CAS 182133-25-1|Arzoxifene

Introduction：Basic information about CAS 182133-25-1|Arzoxifene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameArzoxifene
CAS Number182133-25-1Molecular Weight475.59900
Density1.234g/cm3Boiling Point656.4ºC at 760mmHg
Molecular FormulaC28H29NO4SMelting Point/
MSDS/Flash Point350.8ºC

Names

Name2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol
SynonymMore Synonyms

Arzoxifene BiologicalActivity

DescriptionArzoxifene (LY353381) is an orally active selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breast cancer and endometrium, with equally strong favorable estrogenic effects on bone and lipid profile[1].
Related CatalogSignaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>Metabolic Disease
Target

estrogen[1]

In VitroArzoxifene reduces estrogen receptor expression in endometrial cancer cell lines (ECC-1)[1].
In VivoArzoxifene inhibits MCF-7 breast cancer xenograft growth in oophorectomized athymic mice. Arzoxifene is reported to prevent body weight increase in oophorectomized rats[1].
References

[1]. Jackson LR, et al. Arzoxifene: the evidence for its development in the management of breast cancer. Core Evid. 2008;2(4):251-258.

Chemical & Physical Properties

Density1.234g/cm3
Boiling Point656.4ºC at 760mmHg
Molecular FormulaC28H29NO4S
Molecular Weight475.59900
Flash Point350.8ºC
Exact Mass475.18200
PSA79.40000
LogP6.87740
Vapour Pressure7.85E-18mmHg at 25°C
Index of Refraction1.635
InChIKeyMCGDSOGUHLTADD-UHFFFAOYSA-N
SMILESCOc1ccc(-c2sc3cc(O)ccc3c2Oc2ccc(OCCN3CCCCC3)cc2)cc1

Synonyms

Arzoxifene
UNII-E569WG6E60
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