Introduction：Basic information about CAS 82354-38-9|Humantenmine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Humantenmine |
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| CAS Number | 82354-38-9 | Molecular Weight | 326.390 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 463.6±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H22N2O3 | Melting Point | / |
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| MSDS | / | Flash Point | 234.2±31.5 °C |
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Names
| Name | Humantenmine |
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| Synonym | More Synonyms |
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Humantenmine BiologicalActivity
| Description | Humantenmine, a newalkaloid isolated from Gelsemium elegan Banth in China, has the potential for pain and rheumatic arthritis treatment[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | Humantenmine (HMT) decreases the 14-day survival rate of the mice to 17% after they are intragastrically treated with HMT, along with hepatic injury and increasing alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels. CYP3A4/5 mediates the metabolism and detoxification of HMT[1][2]. |
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| References | [1]. Kun Yang, et al. Development and In-House Validation of a Sensitive LC-MS/MS Method for Simultaneous Quantification of Gelsemine, Koumine and Humantenmine in Porcine Plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 15;1076:54-60. [2]. Rongjin Sun, et al. CYP3A4/5 Mediates the Metabolic Detoxification of Humantenmine, a Highly Toxic Alkaloid From Gelsemium Elegans Benth. J Appl Toxicol. 2019 Sep;39(9):1283-1292. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 463.6±55.0 °C at 760 mmHg |
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| Molecular Formula | C19H22N2O3 |
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| Molecular Weight | 326.390 |
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| Flash Point | 234.2±31.5 °C |
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| Exact Mass | 326.163055 |
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| PSA | 51.13000 |
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| LogP | 3.68 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.712 |
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| InChIKey | BIGABVPVCRHEES-NKZRWYIWSA-N |
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| SMILES | CCC1=NC2CC3(C(=O)N(OC)c4ccccc43)C3CC1C2CO3 |
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Safety Information
Synonyms
| (3S,3'R,3a'S,6'R,8a'S)-2'-ethyl-1-methoxy-3a',4',8',8a'-tetrahydro-3'H,6'H-spiro[indole-3,7'-[3,6]methanooxepino[4,3-b]pyrrol]-2(1H)-one |
| Gelsedine, 4,20-didehydro- |
| (1'R,3S,4'S,7'R,8'S)-6'-Ethyl-1-methoxyspiro[indole-3,2'-[10]oxa[5]azatricyclo[5.3.1.0]undec[5]en]-2(1H)-one |
