CAS 5897-18-7|Cyclizine dihydrochloride

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TL6490000

CHEMICAL NAME :

Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride

CAS REGISTRY NUMBER :

5897-18-7

LAST UPDATED :

199606

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C18-H22-N2.2Cl-H

MOLECULAR WEIGHT :

339.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

69 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :

JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,279,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

11928 mg/kg/12W-C

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 112,297,1954