Introduction：Basic information about CAS 63585-09-1|Foscarnet sodium, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Foscarnet sodium |
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| CAS Number | 63585-09-1 | Molecular Weight | 191.951 |
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| Density | / | Boiling Point | 270-272°C |
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| Molecular Formula | CNa3O5P | Melting Point | 62-65 °C(lit.) |
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| MSDS | / | Flash Point | 270-272°C |
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Names
| Name | trisodium phosphonoformate |
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| Synonym | More Synonyms |
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Foscarnet sodium BiologicalActivity
| Description | Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA Synthesis |
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| In Vitro | Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2]. |
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| References | [1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. [2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24. |
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Chemical & Physical Properties
| Boiling Point | 270-272°C |
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| Melting Point | 62-65 °C(lit.) |
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| Molecular Formula | CNa3O5P |
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| Molecular Weight | 191.951 |
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| Flash Point | 270-272°C |
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| Exact Mass | 191.917648 |
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| PSA | 113.13000 |
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| InChIKey | DFHAXXVZCFXGOQ-UHFFFAOYSA-K |
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| SMILES | O=C([O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+] |
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| Storage condition | -20℃ |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- SY8200000
- CHEMICAL NAME :
- Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt
- CAS REGISTRY NUMBER :
- 63585-09-1
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C-O5-P.3Na
- MOLECULAR WEIGHT :
- 191.95
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 2400 mg/kg/6D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,216,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 384 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4215113
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Safety Information
| Hazard Codes | Xi |
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| Risk Phrases | R36/37/38:Irritating to eyes, respiratory system and skin . |
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| Safety Phrases | S26-S36 |
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| RIDADR | UN 2811 6.1/PG 3 |
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| WGK Germany | 3 |
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| Packaging Group | II |
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| HS Code | 2942000000 |
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Customs
Synonyms
| Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt (1:3) |
| Trisodium dioxidophosphinecarboxylate oxide |
| Foscanet sodium |
| Triapten |
| Foscarnet sodium |
| phosphoranecarboxylic acid, dihydroxy-, oxide, trisodium salt |
| foscarnet sodim |
| MFCD00013973 |
| trisodium dioxidophosphanecarboxylate oxide |
| SODIUM FOSCARNET |
| Phenytion Sodium |
| Foscavir |
| trisodium phosphonoformate |
| FOSCARNET TRISODIUM SALT |
| phosphonoformate sodium salt |
