Introduction：Basic information about CAS 3486-67-7|palmatine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | palmatine |
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| CAS Number | 3486-67-7 | Molecular Weight | 352.403 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C21H22NO4+ | Melting Point | 205ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | palmatine |
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| Synonym | More Synonyms |
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palmatine BiologicalActivity
| Description | Palmatine is an orally active and irreversible indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor. Palmatine can ameliorate DSS-induced colitis by mitigating colonic injury, preventing gut microbiota dysbiosis, and regulating tryptophan catabolism. Palmatine has the potential for colitis treatment[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Indoleamine 2,3-Dioxygenase (IDO)Research Areas >>Inflammation/Immunology |
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| Target | IDO1 |
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| In Vitro | Palmatine exhibits more potent IDO-1 inhibitory activity , which IC50 on rhIDO-1 is 157μM, and on HEK 293-hIDO-1 is 3 μM[1]. |
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| In Vivo | Palmatine (oral administration; 50 or 100 mg/kg, 7 days) has less distortion of epithelium, and fewer infiltrations of inflammatory cells, resulting in significantly lower histopathological scores, it also significantly suppresses the colonic MPO activity[1]. Animal Model: DSS- induced Colitis BALB/c mice model[1] Dosage: 50 or 100 mg/kg; 7 days Administration: Oral administration Result: Ameliorated DSS-induced colitis and prevented infiltration of inflammatory cells. |
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| References | [1]. Zhang XJ, et al. Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota.Pharmacol Res. 2018 Nov;137:34-46. |
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Chemical & Physical Properties
| Melting Point | 205ºC |
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| Molecular Formula | C21H22NO4+ |
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| Molecular Weight | 352.403 |
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| Exact Mass | 352.154327 |
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| PSA | 40.80000 |
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| LogP | -1.12 |
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| InChIKey | QUCQEUCGKKTEBI-UHFFFAOYSA-N |
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| SMILES | COc1cc2c(cc1OC)-c1cc3ccc(OC)c(OC)c3c[n+]1CC2 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DR9890000
- CHEMICAL NAME :
- Berbinium, 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-
- CAS REGISTRY NUMBER :
- 3486-67-7
- BEILSTEIN REFERENCE NO. :
- 1555498
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C21-H22-N-O4
- MOLECULAR WEIGHT :
- 352.44
- WISWESSER LINE NOTATION :
- T D6 B666 KN&TT&J GO1 HO1 PO1 QO1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,129,1968
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Calystigine |
| 7,8,13,13a-tetradehydro-2,3,9,10-tetramethoxyberbinium |
| MFCD00221758 |
| palmatine |
| Burasaine |
| 2,3,9,10-tetramethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium |
| 2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolinium |
| palmatin |
| berbericinine |
| 7,8,13,13a-tetrahydro-2,3,9,10-tetramethoxyberbinium |
| Dibenzo[a,g]quinolizinium, 5,6-dihydro-2,3,9,10-tetramethoxy- |
| o,o-dimethyldemethyleneberberine |
| Hindarinine |
| 5,6-Dihydro-2,3,9,10-tetramethoxy-dibenzo[a,g]quinolizinium |
| Common fibraurea stem |
