CAS 347840-07-7|Doxepin D3 Hydrochloride

Introduction：Basic information about CAS 347840-07-7|Doxepin D3 Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameDoxepin D3 Hydrochloride
CAS Number347840-07-7Molecular Weight318.856
Density/Boiling Point64.0-65.0 °C at 760 mmHg
Molecular FormulaC19H19D3ClNOMelting Point162-164ºC
MSDS/Flash Point9℃
Symbol
GHS02, GHS06, GHS08		Signal WordDanger

Names

NameDoxepin-D3 hydrochloride
SynonymMore Synonyms

Doxepin D3 Hydrochloride BiologicalActivity

DescriptionDoxepin D3 Hydrochloride is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant used as a sedative. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].
Related CatalogSignaling Pathways >>Immunology/Inflammation >>Histamine ReceptorSignaling Pathways >>Metabolic Enzyme/Protease >>Cytochrome P450Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Histamine Receptor
Target

Histamine receptor H1; CYP450 2C19 and CYP450 1A2[2]

References

[1]. Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63.

[2]. Gillman PK1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48.

Chemical & Physical Properties

Boiling Point64.0-65.0 °C at 760 mmHg
Melting Point162-164ºC
Molecular FormulaC19H19D3ClNO
Molecular Weight318.856
Flash Point9℃
Exact Mass318.157837
PSA12.47000
LogP4.76440
InChIKeyMHNSPTUQQIYJOT-NIIDSAIPSA-N
SMILESCN(C)CCC=C1c2ccccc2COc2ccccc21.Cl
Storage conditionHygroscopic, -20°C Freezer, Under Inert Atmosphere
StabilityStore in Freezer at -20°C

Safety Information

Symbol
GHS02, GHS06, GHS08
Signal WordDanger
Hazard StatementsH225-H301 + H311 + H331-H370
Precautionary StatementsP210-P260-P280-P301 + P310-P311
Hazard CodesF,T
Risk Phrases11-23/24/25-39/23/24/25
Safety Phrases7-16-36/37-45
RIDADRUN1230 - class 3 - PG 2 - Methanol, solution

Synonyms

1-Propanamine, 3-dibenz[b,e]oxepin-11(6H)-ylidene-N-methyl-N-(methyl-d)-, hydrochloride (1:1)
3-(Dibenzo[b,e]oxepin-11(6H)-ylidene)-N-methyl-N-(H)methyl-1-propanamine hydrochloride (1:1)
3-(6H-benzo[c][1]benzoxepin-11-ylidene)-N-methyl-N-(trideuteriomethyl)propan-1-amine,hydrochloride
Doxepin-d3Hydrochloride
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