CAS 341001-38-5|Nucleozin

Introduction：Basic information about CAS 341001-38-5|Nucleozin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Nucleozin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles1
6. Synonyms

Common Name	Nucleozin
CAS Number	341001-38-5	Molecular Weight	426.85300
Density	1.371	Boiling Point	673.8ºC at 760 mmHg
Molecular Formula	C₂₁H₁₉ClN₄O₄	Melting Point	/
MSDS	ChineseUSA	Flash Point	361.3ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone
Synonym	More Synonyms

Nucleozin BiologicalActivity

Description	Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. IC50 Value: Target: Influenza Virus NPNucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.
Related Catalog	Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection
References	[1]. Kao, Richard Y. et al. Identification of influenza A nucleoprotein as an antiviral target.Nature Biotechnology (2010), 28(6), 600-605. [2]. Hung HC, Liu CL, Hsu JT, Horng JT, Fang MY, Wu SY, Ueng SH, Wang MY, Yaw CW, Hou MH.Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching.Anal Chem. 2012 Aug 7;84(15):6391-9. Epub 2012 Jul 10. [3]. Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH.High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19151-6. Epub 2010 Oct 25. [4]. Kao RY, Yang D, Lau LS, Tsui WH, Hu L, Dai J, Chan MP, Chan CM, Wang P, Zheng BJ, Sun J, Huang JD, Madar J, Chen G, Chen H, Guan Y, Yuen KY.Identification of influenza A nucleoprotein as an antiviral target.Nat Biotechnol. 2010 Jun;28(6):600-5. Epub 2010 May 30.

Description

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. IC50 Value: Target: Influenza Virus NPNucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC50 is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.

Related Catalog

Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>Infection

References

[1]. Kao, Richard Y. et al. Identification of influenza A nucleoprotein as an antiviral target.Nature Biotechnology (2010), 28(6), 600-605.

[2]. Hung HC, Liu CL, Hsu JT, Horng JT, Fang MY, Wu SY, Ueng SH, Wang MY, Yaw CW, Hou MH.Development of an anti-influenza drug screening assay targeting nucleoproteins with tryptophan fluorescence quenching.Anal Chem. 2012 Aug 7;84(15):6391-9. Epub 2012 Jul 10.

[3]. Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH.High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19151-6. Epub 2010 Oct 25.

[4]. Kao RY, Yang D, Lau LS, Tsui WH, Hu L, Dai J, Chan MP, Chan CM, Wang P, Zheng BJ, Sun J, Huang JD, Madar J, Chen G, Chen H, Guan Y, Yuen KY.Identification of influenza A nucleoprotein as an antiviral target.Nat Biotechnol. 2010 Jun;28(6):600-5. Epub 2010 May 30.

Chemical & Physical Properties

Density	1.371
Boiling Point	673.8ºC at 760 mmHg
Molecular Formula	C₂₁H₁₉ClN₄O₄
Molecular Weight	426.85300
Flash Point	361.3ºC
Exact Mass	426.10900
PSA	95.40000
LogP	4.70010
Index of Refraction	1.631
InChIKey	OWXBJAPOSQSWAO-UHFFFAOYSA-N
SMILES	Cc1onc(-c2ccccc2)c1C(=O)N1CCN(c2ccc([N+](=O)[O-])cc2Cl)CC1
Storage condition	2-8℃

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
RIDADR	UN 2811 6.1 / PGIII

Articles1

A GFP-tagged nucleoprotein-based aggregation assay for anti-influenza drug discovery and antibody development.

Analyst 138(20) , 6073-80, (2013)

Influenza is a viral pandemic that affects millions of people worldwide. Seasonal variations due to genetic shuffling and antigenic drifts in the influenza viruses have necessitated continual updating...

Synonyms

Nucleozin|

(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(5-methyl-3-phenylisoxazol-4-yl)methanone

[4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-[3-phenyl-5-methylisoxazol-4-yl]methanone

Nucleozin

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