CAS 770-05-8|Octopamine hydrochloride

Introduction：Basic information about CAS 770-05-8|Octopamine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Octopamine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles3
7. Synonyms

Common Name	Octopamine hydrochloride
CAS Number	770-05-8	Molecular Weight	189.639
Density	/	Boiling Point	360.7ºC at 760 mmHg
Molecular Formula	C₈H₁₂ClNO₂	Melting Point	~170 °C (dec.)(lit.)
MSDS	ChineseUSA	Flash Point	172ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	Octopamine hydrochloride
Synonym	More Synonyms

Octopamine hydrochloride BiologicalActivity

Description	Octopamine Hydrochloride is an endogenous biogenic amine that is closely related to norepinephrine, and has effects on the adrenergic and dopaminergic systems.Target: Dopamine Receptor; Adrenergic ReceptorOctopamine is present in relatively high concentrations in neuronal as well as in non-neuronal tissues of most invertebrate species studied, and modulates almost every physiological process. Octopamine acts as neurohormone including desensitization of sensory inputs, influence on learning and memory, or regulation of the mood of the animal in the central nervous system. Octopamine is the only neuroactive non-peptide transmitter whose physiological role is restricted to invertebrates, and all octopamine receptors belong to the family of G-protein coupled receptors [1].Octopamine (10 μM) injected into the mushroom body (MB) calyces or the antennal lobe but not the lateral protocerebral lobe produces a lasting, pairing-specific enhancement of extension of the proboscis. Octopamine (10 μM) injected into the MB calyces results in an additional pairing-specific effect, because it does not lead to an acquisition but a consolidation after conditioning [2]. Octopamine treatment significantly elevates levels of octopamine in the brain and caused a significant dose-dependent increase in the number of new foragers. Octopamine treatment is effective only when given to bees old enough to forage, i.e., older than 4 days of age. Octopamine influences division of labor in honey bee colonies [3].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorNatural Products >>OthersResearch Areas >>Neurological Disease
References	[1]. Roeder, T., Octopamine in invertebrates. Prog Neurobiol, 1999. 59(5): p. 533-61. [2]. Hammer, M. and R. Menzel, Multiple sites of associative odor learning as revealed by local brain microinjections of octopamine in honeybees. Learn Mem, 1998. 5(1-2): p. 146-56. [3]. Schulz, D.J. and G.E. Robinson, Octopamine influences division of labor in honey bee colonies. J Comp Physiol A, 2001. 187(1): p. 53-61.

Description

Octopamine Hydrochloride is an endogenous biogenic amine that is closely related to norepinephrine, and has effects on the adrenergic and dopaminergic systems.Target: Dopamine Receptor; Adrenergic ReceptorOctopamine is present in relatively high concentrations in neuronal as well as in non-neuronal tissues of most invertebrate species studied, and modulates almost every physiological process. Octopamine acts as neurohormone including desensitization of sensory inputs, influence on learning and memory, or regulation of the mood of the animal in the central nervous system. Octopamine is the only neuroactive non-peptide transmitter whose physiological role is restricted to invertebrates, and all octopamine receptors belong to the family of G-protein coupled receptors [1].Octopamine (10 μM) injected into the mushroom body (MB) calyces or the antennal lobe but not the lateral protocerebral lobe produces a lasting, pairing-specific enhancement of extension of the proboscis. Octopamine (10 μM) injected into the MB calyces results in an additional pairing-specific effect, because it does not lead to an acquisition but a consolidation after conditioning [2]. Octopamine treatment significantly elevates levels of octopamine in the brain and caused a significant dose-dependent increase in the number of new foragers. Octopamine treatment is effective only when given to bees old enough to forage, i.e., older than 4 days of age. Octopamine influences division of labor in honey bee colonies [3].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorNatural Products >>OthersResearch Areas >>Neurological Disease

References

[1]. Roeder, T., Octopamine in invertebrates. Prog Neurobiol, 1999. 59(5): p. 533-61.

[2]. Hammer, M. and R. Menzel, Multiple sites of associative odor learning as revealed by local brain microinjections of octopamine in honeybees. Learn Mem, 1998. 5(1-2): p. 146-56.

[3]. Schulz, D.J. and G.E. Robinson, Octopamine influences division of labor in honey bee colonies. J Comp Physiol A, 2001. 187(1): p. 53-61.

Chemical & Physical Properties

Boiling Point	360.7ºC at 760 mmHg
Melting Point	~170 °C (dec.)(lit.)
Molecular Formula	C₈H₁₂ClNO₂
Molecular Weight	189.639
Flash Point	172ºC
Exact Mass	189.055649
PSA	66.48000
LogP	1.88660
InChIKey	PUMZXCBVHLCWQG-UHFFFAOYSA-N
SMILES	Cl.NCC(O)c1ccc(O)cc1
Storage condition	Desiccate at RT
Stability	Stable.
Water Solubility	soluble

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H312 + H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful
Risk Phrases	R20/21/22
Safety Phrases	S36
RIDADR	3249
WGK Germany	3
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2922199090

Customs

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles3

Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor.

Br. J. Pharmacol. 122 , 191-198, (1997)

1. In this study we have compared the abilities of the enantiomers of the structural isomers of the phenolamines, octopamine and synephrine, and the catecholamines, noradrenaline and adrenaline, to co...

Octopamine in invertebrates.

Prog. Neurobiol. 59 , 533, (1999)

Octopamine (OA), a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. It is present in relatively high concentr...

Octopamine receptors in the honey bee and locust nervous system: pharmacological similarities between homologous receptors of distantly related species.

Br. J. Pharmacol. 130 , 587-594, (2000)

Honey bees are perhaps the most versatile models to study the cellular and pharmacological basis underlying behaviours ranging from learning and memory to sociobiology. For both aspects octopamine (OA...

Synonyms

Benzenemethanol, α-(aminomethyl)-4-hydroxy-, hydrochloride (1:1)

Octopamine hydrochloride

4-(2-amino-1-hydroxyethyl)phenol hydrochloride

Octopamine HCL

UNII:37YAS5L9HQ

(±)-Octopamine hydrochloride

DL-Octopamine hydrochloride

EINECS 212-216-4

MFCD00012881

4-(2-Amino-1-hydroxyethyl)phenol hydrochloride (1:1)

Octopamine (hydrochloride)

Recommended......