CAS 92134-98-0|Fosphenytoin (disodium)

Introduction：Basic information about CAS 92134-98-0|Fosphenytoin (disodium), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Fosphenytoin (disodium) BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Fosphenytoin (disodium)
CAS Number	92134-98-0	Molecular Weight	406.23800
Density	/	Boiling Point	/
Molecular Formula	C₁₆H₁₃N₂Na₂O₆P	Melting Point	220ºC
MSDS	/	Flash Point	/
Symbol	GHS06	Signal Word	Danger

Names

Name	disodium,(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
Synonym	More Synonyms

Fosphenytoin (disodium) BiologicalActivity

Description	Fosphenytoin sodium is a phenytoin prodrug with similar anticonvulsant properties.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
In Vivo	Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.)-treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed[1]. In fosphenytoin (84 mg/kg)-treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg)[2].
Animal Admin	A total of four groups of rats, including normal (n=2), sham operated (n=2), ischemia with saline-treated (n=2), and ischemia with fosphenytoin-treated (n=2), are studied. Postischemic rats in saline-treated and fosphenytoin-treated groups receive a single i.m. injection of saline or fosphenytoin (30 mg/kg), respectively, in the right hind limb 5 minutes after resuscitation. Sham-operated animals are treated similarly except for chest compression. All rats are killed on the 7th postischemic day by decapitation. Brains are immediately removed, bisected longitudinally, and immersed in 4% buffered neutral formaldehyde containing 0.25% glutaraldehyde for a minimum of 2 days at 4°C. Portions of the brain containing the dorsal hippocampus are coronally sectioned with a vibratome at 40 μm. With the aid of a dissecting microscope, rectangular blocks of about 1 mm2 in size encompassing the mid-CA1 region from sections that approximate Bregma -3.6 are dissected, postfixed in 2% osmium tetroxide, and dehydrated in ascending concentrations of ethanol before being embedded in Araldite 502. Sections of polymerized blocks 1 μm thick are cut and toluidine blue stained for light microscopic examination.
References	[1]. Chan SA, et al. Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia. Acta Neurochir (Wien). 1998;140(2):175-80. [2]. Loscher W, et al. Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin. Epilepsy Res. 1998 Mar;30(1):69-76.

Chemical & Physical Properties

Melting Point	220ºC
Molecular Formula	C₁₆H₁₃N₂Na₂O₆P
Molecular Weight	406.23800
Exact Mass	406.03100
PSA	131.64000
LogP	2.69190
InChIKey	GQPXYJNXTAFDLT-UHFFFAOYSA-L
SMILES	O=C1NC(c2ccccc2)(c2ccccc2)C(=O)N1COP(=O)([O-])[O-].[Na+].[Na+]
Storage condition	2-8°C
Water Solubility	H2O: ≥15mg/mL

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	Missing Phrase - N15.00950417
Hazard Codes	T
Risk Phrases	45-61-22
Safety Phrases	53-36/37-45
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933790090

Customs

HS Code	2933790090
Summary	2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Synonyms

Pro-Epanutin

ACC 9653-010

ACC 9653

Fosphenytoin disodium salt

CI 982

Cerebyx

Fosphenytoin sodium

Fosphenytoin (disodium)

Recommended......