CAS 78432-77-6|Deacetyltaxol
Introduction：Basic information about CAS 78432-77-6|Deacetyltaxol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Deacetyltaxol | ||
|---|---|---|---|
| CAS Number | 78432-77-6 | Molecular Weight | 811.870 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 959.5±65.0 °C at 760 mmHg |
| Molecular Formula | C45H49NO13 | Melting Point | 182-184ºC |
| MSDS | / | Flash Point | 534.1±34.3 °C |
Names
| Name | Deacetyltaxol |
|---|---|
| Synonym | More Synonyms |
Deacetyltaxol BiologicalActivity
| Description | 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc[1]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/Tubulin |
| Target | tubulin[2] |
| References | [1]. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44(3):312-9. [2]. Michel Colin, et al. Process for the preparation of taxol and 10-deacetyltaxol. US4857653A. [3]. Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 959.5±65.0 °C at 760 mmHg |
| Melting Point | 182-184ºC |
| Molecular Formula | C45H49NO13 |
| Molecular Weight | 811.870 |
| Flash Point | 534.1±34.3 °C |
| Exact Mass | 811.320374 |
| PSA | 215.22000 |
| LogP | 6.74 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.652 |
| InChIKey | TYLVGQKNNUHXIP-MHHARFCSSA-N |
| SMILES | CC(=O)OC12COC1CC(O)C1(C)C(=O)C(O)C3=C(C)C(OC(=O)C(O)C(NC(=O)c4ccccc4)c4ccccc4)CC(O)(C(OC(=O)c4ccccc4)C21)C3(C)C |
| Storage condition | -20°C Freezer |
Safety Information
| Safety Phrases | 24/25 |
|---|---|
| HS Code | 29329990 |
Synonyms
| benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |
| 7-epi-10-deacetyltaxol |
| b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester |
| (2α,5β,7β,10β,13α)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| 7-EPI-10-DEACETYL PACLITAXEL |
| 10-DEACETYLTAXOL |
| 10-Desacetyl Paclitaxel |
| (2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| 10-Desacetyltaxol |
| Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,1 3-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- |
| 10-Deacetylpaclitaxel |
| 10-DAT |
