Introduction：Basic information about CAS 477-27-0|Colchiceine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Colchiceine |
|---|
| CAS Number | 477-27-0 | Molecular Weight | 385.41000 |
|---|
| Density | 1.31g/cm3 | Boiling Point | 731.5ºC at 760mmHg |
|---|
| Molecular Formula | C21H23NO6 | Melting Point | 172-174ºC |
|---|
| MSDS | / | Flash Point | 396.2ºC |
|---|
Names
| Name | Colchiceine |
|---|
| Synonym | More Synonyms |
|---|
Chemical & Physical Properties
| Density | 1.31g/cm3 |
|---|
| Boiling Point | 731.5ºC at 760mmHg |
|---|
| Melting Point | 172-174ºC |
|---|
| Molecular Formula | C21H23NO6 |
|---|
| Molecular Weight | 385.41000 |
|---|
| Flash Point | 396.2ºC |
|---|
| Exact Mass | 385.15300 |
|---|
| PSA | 94.09000 |
|---|
| LogP | 2.95950 |
|---|
| Vapour Pressure | 1.83E-22mmHg at 25°C |
|---|
| Index of Refraction | 1.61 |
|---|
| InChIKey | PRGILOMAMBLWNG-HNNXBMFYSA-N |
|---|
| SMILES | COc1cc2c(c(OC)c1OC)-c1ccc(O)c(=O)cc1C(NC(C)=O)CC2 |
|---|
Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- GH0520000
- CHEMICAL NAME :
- Colchiceine
- CAS REGISTRY NUMBER :
- 477-27-0
- BEILSTEIN REFERENCE NO. :
- 2824078
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C21-H23-N-O6
- MOLECULAR WEIGHT :
- 385.45
- WISWESSER LINE NOTATION :
- L B677 MV&T&J CO1 DO1 EO1 JMV1 NQ
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 43 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2500 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 84 mg/kg
- TOXIC EFFECTS :
- Blood - hemorrhage
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Sperm Morphology
MUTATION DATA - TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 250 nmol/L
- REFERENCE :
- AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 137,779,1990
|
Safety Information
| Hazard Codes | T+ |
|---|
| HS Code | 2924299090 |
|---|
Customs
| HS Code | 2924299090 |
|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
|---|
Synonyms
