CAS 58652-20-3|Nomegestrol acetate
Introduction：Basic information about CAS 58652-20-3|Nomegestrol acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Nomegestrol acetate | ||
|---|---|---|---|
| CAS Number | 58652-20-3 | Molecular Weight | 370.482 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 507.3±50.0 °C at 760 mmHg |
| Molecular Formula | C23H30O4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 219.8±30.2 °C |
| Symbol | GHS08, GHS09 | Signal Word | Warning |
Names
| Name | Nomegestrol acetate |
|---|---|
| Synonym | More Synonyms |
Nomegestrol acetate BiologicalActivity
| Description | Nomegestrol acetate is a potent, highly selective progestogen, which is characterized as a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors, including the androgen and glucocorticoid receptors[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Progesterone ReceptorResearch Areas >>Endocrinology |
| Target | Progesterone receptor[1] |
| References | [1]. Mueck AO, et al. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011 May;76(6):531-9. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 507.3±50.0 °C at 760 mmHg |
| Molecular Formula | C23H30O4 |
| Molecular Weight | 370.482 |
| Flash Point | 219.8±30.2 °C |
| Exact Mass | 370.214417 |
| PSA | 60.44000 |
| LogP | 3.34 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.554 |
| InChIKey | IIVBFTNIGYRNQY-YQLZSBIMSA-N |
| SMILES | CC(=O)OC1(C(C)=O)CCC2C3C=C(C)C4=CC(=O)CCC4C3CCC21C |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1050 ug/kg/21D-I
- TOXIC EFFECTS :
- Endocrine - changes in luteinizing hormone Endocrine - estrogenic Endocrine - effect on menstrual cycle
- REFERENCE :
- BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year: 94,1199,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 9,657,1984 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 4 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,710,1983
Safety Information
| Symbol | GHS08, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H361fd-H400 |
| Precautionary Statements | P280 |
| Hazard Codes | N |
| Risk Phrases | 63-50 |
| Safety Phrases | 61 |
| RIDADR | UN 3077 9 / PGIII |
| RTECS | RC8899200 |
Articles30
More Articles| Changing convention in combination oral contraceptives: estradiol and nomegestrol acetate in a monophasic 24/4 regimen. J. Fam. Plann. Reprod. Health Care 39(3) , 211-6, (2013) Initial oral contraceptive regimens were characterised by high doses of ethinylestradiol (EE) and a progestogen in a 21-day regimen that either included seven additional hormone-free tablets or simply... | |
| A new contraceptive pill containing 17β-estradiol and nomegestrol acetate. Womens. Health (Lond. Engl.) 9(1) , 13-23, (2013) Most combined oral contraceptive pills contain ethinyl estradiol (EE) with progestins. In order to minimize the pill's cardiovascular risks, the concept of using 17β-estradiol (E2), the endogenous est... | |
| The “newer” progestogens and postmenopausal hormone therapy (HRT) J. Steroid Biochem. Mol. Biol. 142 , 48-51, (2014) • The “newer” progestogens have a high bioavailability. • The “newer” progestogens have a sufficient progestogenic effect. • The “newer” progestogens do not cause undue side effects. • The “newer” pro... |
Synonyms
| [(8S,9S,10R,13S,14S,17R)-17-acetyl-6,13-dimethyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate |
| EINECS 261-379-8 |
| 6-Methyl-3,20-dioxo-19-norpregna-4,6-dien-17-yl acetate |
| Lutenyl |
| (17a)-17-Acetyl-6-methyl-3-oxoestra-4,6-dien-17-yl acetate |
| MFCD00941390 |
| 17-Acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione |
| Nomegestrol acetate |
| Estra-4,6-dien-3-one, 17-acetyl-17-(acetyloxy)-6-methyl-, (17α)- |
| 19-normegestrol acetate |
