CAS 71751-41-2|Avermectin

Introduction：Basic information about CAS 71751-41-2|Avermectin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Avermectin BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles29
8. Synonyms

Common Name	Avermectin
CAS Number	71751-41-2	Molecular Weight	1732.13
Density	1.2±0.1 g/cm3	Boiling Point	940.9±65.0 °C at 760 mmHg
Molecular Formula	C₉₅H₁₄₂O₂₈	Melting Point	150-155°C
MSDS	ChineseUSA	Flash Point	268.1±27.8 °C
Symbol	GHS06, GHS08, GHS09	Signal Word	Danger

Names

Name	Abamectin
Synonym	More Synonyms

Avermectin BiologicalActivity

Description	Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic. IC50 Value: /Target: AntiparasiticAvermectin B1 is a mixture of avermectins containing more than 80% avermectin B1a and less than 20% avermectin B1b. These two components, B1a and B1b have very similar biological and toxicological properties. The avermectins are insecticidal and antihelmintic compounds derived from various laboratory broths fermented by the soil bacterium Streptomyces avermitilis. Avermectin B1 is a natural fermentation product of this bacterium.
Related Catalog	Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection
References	[1]. Mogg TD, Pollitt CC, Willmore JP, Thompson H.Efficacy of avermectin B1 given orally against equine intestinal strongyles and Onchocera microfilaria.Aust Vet J. 1990 Nov;67(11):399-401. [2]. De Chaneet GC, Casey R, Dixon FF, Besier RB, Mitchell RK.Effect of avermectin B1 and benzimidazole anthelmintics on worm egg output of treated cattle.Aust Vet J. 1988 Mar;65(3):85-6. [3]. Seaman JT, Eagleson JS, Carrigan MJ, Webb RF.Avermectin B1 toxicity in a herd of Murray Grey cattle.Aust Vet J. 1987 Sep;64(9):284-5. [4]. Murty US, Jyothi KN, Jamil K.Effect of avermectin B1 (L-676) a metabolite from Streptomyces avermilitis on immatures of Culex quinquefasciatus.Indian J Med Res. 1987 May;85:539-41. [5]. Parrish MD, Roberts RB.Toxicity of avermectin B1 to larval yellowjackets, Vespula maculifrons (Hymenoptera: Vespidae).J Econ Entomol. 1984 Jun;77(3):769-72.

Description

Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic. IC50 Value: /Target: AntiparasiticAvermectin B1 is a mixture of avermectins containing more than 80% avermectin B1a and less than 20% avermectin B1b. These two components, B1a and B1b have very similar biological and toxicological properties. The avermectins are insecticidal and antihelmintic compounds derived from various laboratory broths fermented by the soil bacterium Streptomyces avermitilis. Avermectin B1 is a natural fermentation product of this bacterium.

Related Catalog

Signaling Pathways >>Autophagy >>AutophagySignaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection

References

[1]. Mogg TD, Pollitt CC, Willmore JP, Thompson H.Efficacy of avermectin B1 given orally against equine intestinal strongyles and Onchocera microfilaria.Aust Vet J. 1990 Nov;67(11):399-401.

[2]. De Chaneet GC, Casey R, Dixon FF, Besier RB, Mitchell RK.Effect of avermectin B1 and benzimidazole anthelmintics on worm egg output of treated cattle.Aust Vet J. 1988 Mar;65(3):85-6.

[3]. Seaman JT, Eagleson JS, Carrigan MJ, Webb RF.Avermectin B1 toxicity in a herd of Murray Grey cattle.Aust Vet J. 1987 Sep;64(9):284-5.

[4]. Murty US, Jyothi KN, Jamil K.Effect of avermectin B1 (L-676) a metabolite from Streptomyces avermilitis on immatures of Culex quinquefasciatus.Indian J Med Res. 1987 May;85:539-41.

[5]. Parrish MD, Roberts RB.Toxicity of avermectin B1 to larval yellowjackets, Vespula maculifrons (Hymenoptera: Vespidae).J Econ Entomol. 1984 Jun;77(3):769-72.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	940.9±65.0 °C at 760 mmHg
Melting Point	150-155°C
Molecular Formula	C₉₅H₁₄₂O₂₈
Molecular Weight	1732.13
Flash Point	268.1±27.8 °C
PSA	170.06000
LogP	6.51
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.571

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CL1203000

CHEMICAL NAME :: Avermectin B(sub 1)

CAS REGISTRY NUMBER :: 71751-41-2

LAST UPDATED :: 199409

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,3,1989

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1100 mg/m3/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1740 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 60,289,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: 84600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - domestic

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 42(249-250),41,1988

Safety Information

Symbol	GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H300 + H330-H361d-H372-H410
Precautionary Statements	P201-P260-P273-P301 + P310 + P330-P304 + P340 + P310-P403 + P233
Target Organs	Nervous system
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	T+,N
Risk Phrases	R20
Safety Phrases	36/37/39-45-60-61
RIDADR	2588
RTECS	CL1203000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles29

Toxicity of three insecticides to Lysiphlebus fabarum, a parasitoid of the black bean aphid, Aphis fabae.

J. Insect Sci. 11 , 104, (2011)

The toxicity of three insecticides to Lysiphlebus fabarum (Marshall) (Hymenoptera: Braconidae: Aphidiinae), a parasitoid of Aphis fabae Scopoli (Hemiptera: Aphididae), was investigated using IOBC/wprs...

[Toxicity and bioactivity of several alternative nematocides against Ditylenchus destructor].

Ying Yong Sheng Tai Xue Bao 22(11) , 3026-32, (2011)

By the methods of fumigation and contact assay, this paper determined the toxicity of four kinds of soil fumigants and six kinds of non-fumigants against Ditylenchus destructor. In the meantime, the b...

Determination of active substances in binary mixture antiparasitic veterinary formulations by HPLC.

Acta Pol. Pharm. 68(4) , 467-72, (2011)

The purpose of the study was to develop a simple, versatile HPLC method for the identification and quantification of praziquantel and ivermectin (in Equimax) or praziquantel and abamectin (in Abamitel...

Synonyms

MFCD01769550

EINECS 200-096-6

avomec

mk936

zephyr

affirm

SADDLE

Zephy

AVM

avidec

Avermectin B1

ACIMIC

avid

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