CAS 92665-29-7|(Z)-Cefprozil

Introduction：Basic information about CAS 92665-29-7|(Z)-Cefprozil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (Z)-Cefprozil BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	(Z)-Cefprozil
CAS Number	92665-29-7	Molecular Weight	389.426
Density	1.5±0.1 g/cm3	Boiling Point	803.1±65.0 °C at 760 mmHg
Molecular Formula	C₁₈H₁₉N₃O₅S	Melting Point	76°C
MSDS	/	Flash Point	439.5±34.3 °C

Names

Name	cefprozil
Synonym	More Synonyms

(Z)-Cefprozil BiologicalActivity

Description	Cefprozil (Cefzil) is a second-generation cephalosporin type antibiotic[1].
Related Catalog	Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	803.1±65.0 °C at 760 mmHg
Melting Point	76°C
Molecular Formula	C₁₈H₁₉N₃O₅S
Molecular Weight	389.426
Flash Point	439.5±34.3 °C
Exact Mass	389.104553
PSA	158.26000
LogP	0.06
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.718
Storage condition	-20°C Freezer
Water Solubility	3.3 mg/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI0339000

CHEMICAL NAME :: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl) amino)-8-oxo-3-(1-propenyl)-, (6R-(6-alpha,7-beta(R*)))-, hydrate

CAS REGISTRY NUMBER :: 92665-29-7

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H19-N3-O5-S.H2-O

MOLECULAR WEIGHT :: 407.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 100 mg/kg/5D-I

TOXIC EFFECTS :: Musculoskeletal - joints Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 125,325,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 7500 ug/kg/5D-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema Musculoskeletal - joints Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- Volume(issue)/page/year: 125,325,1994

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1238,1990

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1238,1990 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 gm/kg/4W-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes

REFERENCE :: JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1243,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 14 gm/kg/4W-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting

REFERENCE :: JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 43,1260,1990

Safety Information

Hazard Codes	Xn
Risk Phrases	R22:Harmful if swallowed. R41:Risk of serious damage to eyes. R43:May cause sensitization by skin contact.
Safety Phrases	S26-S36/37/39
RTECS	XZ4380000
HS Code	2941905990

Customs

HS Code	2941905990

Synonyms

Cefprozil

Prozef

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1Z)-1-propen-1-yl]-, (6R,7R)-

5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1Z)-1-propenyl]-, (6R,7R)-

Cefrozil

(6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1Z)-prop-1-en-1-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

CEFPROZIL , (Z)-

(6R,7R)-7-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-8-oxo-3-[(1Z)-1-propen-1-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cephprozyl

5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R,7R)-

MFCD00865082

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