Introduction：Basic information about CAS 6429-04-5|Tetrahydropapaverine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tetrahydropapaverine hydrochloride |
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| CAS Number | 6429-04-5 | Molecular Weight | 379.878 |
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| Density | 1.12g/cm3 | Boiling Point | 475.8ºC at 760 mmHg |
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| Molecular Formula | C20H26ClNO4 | Melting Point | 213-215ºC |
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| MSDS | / | Flash Point | 202.7ºC |
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Names
| Name | Tetrahydropapaverine hydrochloride |
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| Synonym | More Synonyms |
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Tetrahydropapaverine hydrochloride BiologicalActivity
| Description | Tetrahydropapaverine hydrochloride is one of the Tetrahydroisoquinolines. Tetrahydropapaverine hydrochloride has neurotoxic effects on dopamine neurons[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| References | [1]. Koshimura I, et al. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res. 1997 Oct 31;773(1-2):108-16. [2]. Kim EI, et al. Inhibitory effects of tetrahydropapaverine on serotonin biosynthesis in murine mastocytoma P815 cells. Life Sci. 2004 Sep 3;75(16):1949-57. |
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Chemical & Physical Properties
| Density | 1.12g/cm3 |
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| Boiling Point | 475.8ºC at 760 mmHg |
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| Melting Point | 213-215ºC |
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| Molecular Formula | C20H26ClNO4 |
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| Molecular Weight | 379.878 |
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| Flash Point | 202.7ºC |
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| Exact Mass | 379.155029 |
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| PSA | 53.53000 |
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| LogP | 0.69750 |
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| Index of Refraction | 1.549 |
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| InChIKey | VMPLLPIDRGXFTQ-UHFFFAOYSA-N |
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| SMILES | COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1OC.Cl |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NX5070700
- CHEMICAL NAME :
- Isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-1-veratryl-, hydrochloride
- CAS REGISTRY NUMBER :
- 6429-04-5
- LAST UPDATED :
- 198310
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C20-H25-N-O4.Cl-H
- MOLECULAR WEIGHT :
- 379.92
- WISWESSER LINE NOTATION :
- T66 CMT&J B1R CO1 DO1& HO1 IO1 &GH
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,200,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,200,1964
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Safety Information
| Hazard Codes | T: Toxic; |
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| Risk Phrases | 22 |
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| Safety Phrases | 36 |
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| HS Code | 2939190090 |
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Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| EINECS 229-213-9 |
| 1-(3,4-Dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1) |
| Papaverine, 1,2,3,4-tetrahydro-, hydrochloride |
| MFCD00035267 |
| Isoquinoline, 1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-, hydrochloride (1:1) |
