CAS 476-70-0|Boldine
Introduction：Basic information about CAS 476-70-0|Boldine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Boldine | ||
|---|---|---|---|
| CAS Number | 476-70-0 | Molecular Weight | 327.374 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 529.3±50.0 °C at 760 mmHg |
| Molecular Formula | C19H21NO4 | Melting Point | 162-164ºC |
| MSDS | ChineseUSA | Flash Point | 273.9±30.1 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol |
|---|---|
| Synonym | More Synonyms |
Boldine BiologicalActivity
| Description | Boldine is an aporphine isoquinoline alkaloid extracted from the root of Litsea cubeba and also possesses these properties, including antioxidant, anti-inflammatory and cytoprotective effects. Boldine suppresses osteoclastogenesis, improves bone destruction by down-regulating the OPG/RANKL/RANK signal pathway and may be a potential therapeutic agent for rheumatoid arthritis[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| Target | OPG/RANKL/RANK[1] |
| References | [1]. Zhao H , et al. Boldine isolated from Litsea cubeba inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 529.3±50.0 °C at 760 mmHg |
| Melting Point | 162-164ºC |
| Molecular Formula | C19H21NO4 |
| Molecular Weight | 327.374 |
| Flash Point | 273.9±30.1 °C |
| Exact Mass | 327.147064 |
| PSA | 62.16000 |
| LogP | 2.32 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.639 |
| InChIKey | LZJRNLRASBVRRX-ZDUSSCGKSA-N |
| SMILES | COc1cc2c(cc1O)CC1c3c(cc(O)c(OC)c3-2)CCN1C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 145 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes
MUTATION DATA - TYPE OF TEST :
- Gene conversion and mitotic recombination
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,145,1991
- TYPE OF TEST :
- Gene conversion and mitotic recombination
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 260,145,1991
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful; |
| Risk Phrases | R22 |
| Safety Phrases | 1-20-24/25-45-36-26 |
| RIDADR | UN 1544 |
| WGK Germany | 3 |
| RTECS | CE0750000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
Articles28
More Articles| Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine. Molecules 17(9) , 10958-70, (2012) The aim of this study was to determine the electronic influence of substituent groups and annelated rings such as oxazole-oxazinone on the physicochemical and photoprotection, antioxidant capacity, to... | |
| Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction. Planta Med. 72(12) , 1157-62, (2006) The extraction methods in selected monographs of the European and the Swiss Pharmacopoeia were compared to pressurized liquid extraction (PLE) with respect to the yield of constituents to be dosed in ... | |
| 8-NH2-boldine, an antagonist of alpha1A and alpha1B adrenoceptors without affinity for the alpha1D subtype: structural requirements for aporphines at alpha1-adrenoceptor subtypes. Planta Med. 71(10) , 897-903, (2005) Structure-activity analysis of 21 aporphine derivatives was performed by examining their affinities for cloned human alpha (1A), alpha (1B) and alpha (1D) adrenoceptors (AR) using membranes prepared f... |
Synonyms
| Boldine chloroform |
| 4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl- |
| Boldin |
| 2,6-dihydroxy-3,5-dimethoxyaporphine |
| 5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol |
| EINECS 207-509-9 |
| 1,10-dimethoxy-2,9-dihydroxyaporphine |
| Uniboldina |
| MFCD00135040 |
| 2,9-Dihydroxy-1,10-dimethoxyaporphine |
| 1,10-Dimethoxy-6aa-aporphine-2,9-diol |
| dl-Boldine |
| Boldine |
| 1,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol |
