Introduction：Basic information about CAS 7729-30-8|(2R)-2-Azetidinecarboxylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (2R)-2-Azetidinecarboxylic acid |
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| CAS Number | 7729-30-8 | Molecular Weight | 101.104 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 242.0±33.0 °C at 760 mmHg |
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| Molecular Formula | C4H7NO2 | Melting Point | 209-211ºC |
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| MSDS | / | Flash Point | 100.1±25.4 °C |
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Names
| Name | (R)-Azetidine-2-carboxylic acid |
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| Synonym | More Synonyms |
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(2R)-2-Azetidinecarboxylic acid BiologicalActivity
| Description | (R)-Azetidine-2-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (R)-Azetidine-2-carboxylic acid is also a alkyl chain-based PROTAC linker that can be |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 242.0±33.0 °C at 760 mmHg |
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| Melting Point | 209-211ºC |
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| Molecular Formula | C4H7NO2 |
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| Molecular Weight | 101.104 |
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| Flash Point | 100.1±25.4 °C |
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| Exact Mass | 101.047676 |
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| PSA | 49.33000 |
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| LogP | -0.83 |
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| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
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| Index of Refraction | 1.499 |
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| InChIKey | IADUEWIQBXOCDZ-GSVOUGTGSA-N |
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| SMILES | O=C(O)C1CCN1 |
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| Storage condition | -20°C Freezer |
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| Stability | Temperature Sensitive - Do Not Heat Above 55°C |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 22 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-Azetidinecarboxylic acid, (2R)- |
| D-Azetidine-2-carboxylic acid |
| (2R)-(+)-Azetidine-2-carboxylic acid |
| (2R)-Azetidine-2-carboxylic acid |
| MFCD00800731 |
| (2R)-2-Azetidinecarboxylic acid |
