CAS 81065-76-1|EUK-134

Introduction：Basic information about CAS 81065-76-1|EUK-134, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. EUK-134 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	EUK-134
CAS Number	81065-76-1	Molecular Weight	416.738
Density	/	Boiling Point	/
Molecular Formula	C₁₈H₁₈ClMnN₂O₄	Melting Point	/
MSDS	USA	Flash Point	/

Names

Name	manganese(2+),2-methoxy-6-[2-[(3-methoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride
Synonym	More Synonyms

EUK-134 BiologicalActivity

Description	EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. EUK-134 is a superoxide dismutase (SOD) mimetics (SODm) with catalase activity. EUK-134 is a mitoprotective antioxidant. EUK-134 reduces the expression of NF-κB, MDA level, and protein carbonylation in H9C2 cells[1][2][3].
Related Catalog	Research Areas >>Cardiovascular Disease
Target	NF-κB
In Vitro	EUK-134 (10-300 μM) is able to improve cell viability and reduces Paraquat (1 mM)-induced cell death significantly via dismutation or scavenging of superoxide anions and reduces hydroxyl radical generation[2]. Higher concentrations of EUK-134 alone (30-300 μM) produces modest but significant reductions in cellular viability; however, this effect is not reflected in cell death measurements made at these concentrations[2]. EUK-134 is a salen-manganese complex with superoxide dismutase and catalase activity.Supplementation with EUK-134 is therefore identified as a novel approach to attenuate cardiac hypertrophy and lends scope for the development of EUK-134 as a therapeutic agent in the management of human cardiovascular disease.EUK-134 is a mitoprotective antioxidant with Mn-superoxide dismutase (Mn SOD) and catalase activity[3]. Cell Viability Assay[2] Cell Line: NRK-52E cells Concentration: 0, 1, 3, 10, 30, 100, and 300 μM Incubation Time: 24 hours Result: Co-incubation with Paraquat (1 mM) and increasing concentrations of EUK-134 (1-300 μM) resulted in a significant reduction in paraquat-induced cellular injury and death at 100 and 300 μM.
References	[1]. P Gianello, et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation. 1996 Dec 15;62(11):1664-6. [2]. Mohamed Samai, et al. Comparison of the effects of the superoxide dismutase mimetics EUK-134 and tempol on paraquat-induced nephrotoxicity. Free Radic Biol Med. 2007 Aug 15;43(4):528-34. [3]. Sreeja Purushothaman, et al. Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. Mol Cell Biochem. 2016 Sep;420(1-2):185-94.

Chemical & Physical Properties

Molecular Formula	C₁₈H₁₈ClMnN₂O₄
Molecular Weight	416.738
Exact Mass	416.033569
PSA	58.62000
LogP	3.09010
Appearance of Characters	, faint to very dark brown
InChIKey	YUZJJFWCXJDFOQ-UHFFFAOYSA-K
SMILES	COc1cccc(C=NCCN=Cc2cccc(OC)c2[O-])c1[O-].[Cl-].[Mn+3]
Storage condition	?20°C
Water Solubility	H2O: soluble2mg/mL, clear (warmed)

Safety Information

RIDADR	NONH for all modes of transport

Synonyms

Phenol, 2,2'-[1,2-ethanediylbis[nitrilo(E)methylidyne]]bis[6-methoxy-, manganese(3+) salt, hydrochloride (1:1:1)

ethylbisiminomethylguaiacol manganese chloride

Manganese(3+) chloride 2,2'-{1,2-ethanediylbis[nitrilo(E)methylylidene]}bis(6-methoxyphenolate) (1:1:1)

I14-7464

EUK-134

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