Introduction：Basic information about CAS 473-90-5|Oxomalonic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Oxomalonic acid |
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| CAS Number | 473-90-5 | Molecular Weight | 118.04500 |
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| Density | 1.832g/cm3 | Boiling Point | 405.2ºC at 760mmHg |
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| Molecular Formula | C3H2O5 | Melting Point | / |
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| MSDS | / | Flash Point | 213ºC |
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Names
| Name | oxomalonic acid |
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| Synonym | More Synonyms |
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Oxomalonic acid BiologicalActivity
| Description | Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC50 of 2.2 μM[1][2]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>HIVResearch Areas >>Infection |
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| References | [1]. Jean A Bernatchez, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. J Biol Chem. 2015 Jan 16;290(3):1474-84. [2]. W R Davis, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39(46):14279-91. |
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Chemical & Physical Properties
| Density | 1.832g/cm3 |
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| Boiling Point | 405.2ºC at 760mmHg |
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| Molecular Formula | C3H2O5 |
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| Molecular Weight | 118.04500 |
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| Flash Point | 213ºC |
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| Exact Mass | 117.99000 |
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| PSA | 91.67000 |
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| Vapour Pressure | 1.06E-07mmHg at 25°C |
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| Index of Refraction | 1.504 |
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| InChIKey | XEEVLJKYYUVTRC-UHFFFAOYSA-N |
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| SMILES | O=C(O)C(=O)C(=O)O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OX7480000
- CHEMICAL NAME :
- Mesoxalic acid
- CAS REGISTRY NUMBER :
- 473-90-5
- BEILSTEIN REFERENCE NO. :
- 1754123
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C3-H2-O5
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 81,1225,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 81,1225,1961
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Safety Information
Customs
| HS Code | 2918300090 |
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| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Synonyms
| MESOXALIC ACID |
| 2-ketomalonic acid |
| Mesoxalate |
| Oxopropanedioic acid |
| 2-Oxomalonsaeure |
| Ketomalonic acid |
| 2-Oxomalonic acid |
| Oxomalonic acid |
| dicarboxylic ketone |
| 2-oxopropanedioic acid |
