CAS 3458-14-8|5'-DEOXYTHYMIDINE
| Common Name | 5'-DEOXYTHYMIDINE | ||
|---|---|---|---|
| CAS Number | 3458-14-8 | Molecular Weight | 352.13 |
| Density | 1.344g/cm3 | Boiling Point | / |
| Molecular Formula | C10H13IN2O4 | Melting Point | 192-193ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | 2′,5′-Dideoxythymidine |
|---|---|
| Synonym | More Synonyms |
5'-DEOXYTHYMIDINE BiologicalActivity
| Description | 5′-Deoxythymidine is a thymidine form which 5' position replaced with hydrogen. 5'-deoxy Thymidine is effective against Bacillus subtilis and Staphylococcus aureus. 5′-Deoxythymidine can be used as a research tool for antiviral and anticancer studies[1]. |
|---|---|
| Related Catalog | Research Areas >>Cancer |
| References | [1]. Hatano A, et al. Impact of unnatural nucleosides on the control of microbial growth. Biocontrol Sci. 2009;14(2):55-60. |
Chemical & Physical Properties
| Density | 1.344g/cm3 |
|---|---|
| Melting Point | 192-193ºC(lit.) |
| Molecular Formula | C10H13IN2O4 |
| Molecular Weight | 352.13 |
| Exact Mass | 226.09500 |
| PSA | 84.32000 |
| Index of Refraction | 1.559 |
| InChIKey | UGUILUGCFSCUKR-GJMOJQLCSA-N |
| SMILES | Cc1cn(C2CC(O)C(C)O2)c(=O)[nH]c1=O |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles6
More Articles| Thymidine inhibits the growth-arrest-specific degradation of thymidine kinase protein in transfected L fibroblasts. J. Mol. Biol. 265(2) , 153-60, (1997) The expression of murine thymidine kinase (TK) is strictly dependent on the growth state of the cell. Expressing epitope-tagged TK in LTK cells, we have previously shown that low TK enzyme levels in G... | |
| Membrane permeation characteristics of 5'-modified thymidine analogs. Mol. Pharmacol. 41(5) , 950-6, (1992) The membrane permeation characteristics of 5'-deoxythymidine (5'-ddThd) and 5'-azido-5'-deoxythymidine (5'-N3-5'-ddThd) were investigated in human erythrocytes, with an inhibitor-stop assay, at 20 deg... | |
| Synthesis and HIV-1 reverse transcriptase inhibitor activity of some 2,5,6-substituted benzoxazole, benzimidazole, benzothiazole and oxazolo(4,5-b)pyridine derivatives. Arzneimittelforschung 53(4) , 266-71, (2003) In this study, the synthesis of some benzoxazoles and their analogues were described and their antiviral activities were studied together with the previously synthesized 2,5,6-trisubstituted benzoxazo... |
Synonyms
| MFCD00057398 |
| 1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione |
| 5'-Deoxythymidine |
