Introduction：Basic information about CAS 182815-44-7|Colesevelam Hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Colesevelam Hydrochloride |
|---|
| CAS Number | 182815-44-7 | Molecular Weight | 618.24900 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | (C13H27N.C12H27N2.C3H7N.C3H5ClO.Cl)x.xHCl | Melting Point | >145℃ (dec.) |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | colesevelam hydrochloride |
|---|
| Synonym | More Synonyms |
|---|
Colesevelam Hydrochloride BiologicalActivity
| Description | Colesevelam (hydrochloride) is a bile acid sequestrant that bind bile acids in the gut. Colesevelam (hydrochloride) inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduced cholesterol levels in patients with cholestatic pruritus and Crohn’s disease. |
|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
|---|
| References | [1]. Potthoff MJ, Potts A, He T, et al. Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice. Am J Physiol Gastrointest Liver Physiol. 2013;304(4):G371-G380. [2]. Cabré N, Duan Y, Llorente C, et al. Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice. Cells. 2021;10(6):1496. |
|---|
Chemical & Physical Properties
| Melting Point | >145℃ (dec.) |
|---|
| Molecular Formula | (C13H27N.C12H27N2.C3H7N.C3H5ClO.Cl)x.xHCl |
|---|
| Molecular Weight | 618.24900 |
|---|
| Exact Mass | 616.43800 |
|---|
| PSA | 62.61000 |
|---|
| LogP | 5.97450 |
|---|
| InChIKey | VTAKZNRDSPNOAU-UHFFFAOYSA-M |
|---|
| SMILES | C=CCN.C=CCNCCCCCCCCCC.C=CCNCCCCCC[N+](C)(C)C.Cl.ClCC1CO1.[Cl-] |
|---|
| Storage condition | -20°C |
|---|
Synonyms
| colesevelam |
| 2-(chloromethyl)oxirane,prop-2-en-1-amine,N-prop-2-enyldecan-1-amine,trimethyl-[6-(prop-2-enylamino)hexyl]azanium,chloride,hydrochloride |
