Introduction：Basic information about CAS 18457-44-8|Taxinine B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Taxinine B |
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| CAS Number | 18457-44-8 | Molecular Weight | 664.74 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 705.4±60.0 °C at 760 mmHg |
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| Molecular Formula | C37H44O11 | Melting Point | / |
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| MSDS | / | Flash Point | 286.7±32.9 °C |
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Names
| Name | Taxinine B |
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| Synonym | More Synonyms |
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Taxinine B BiologicalActivity
| Description | Taxinine B is a taxoid that can be isolated from Japanese Yew Taxus Cuspid. Taxinine B inhibits CaCl2-induced depolymerization of microtubule. Taxinine B is useful for overcoming multidrug resistance in tumor cells[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/Tubulin |
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| References | [1]. Juníchi Kobayashi, et al. Taxuspines A ∼ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells. Tetrahedron. 1994. 50 (25), 7401-7416. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 705.4±60.0 °C at 760 mmHg |
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| Molecular Formula | C37H44O11 |
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| Molecular Weight | 664.74 |
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| Flash Point | 286.7±32.9 °C |
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| Exact Mass | 664.288391 |
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| PSA | 148.57000 |
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| LogP | 5.60 |
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| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
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| Index of Refraction | 1.558 |
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| InChIKey | SLJNSLIEGINNEE-UHFFFAOYSA-N |
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| SMILES | C=C1C(OC(=O)C=Cc2ccccc2)CC(OC(C)=O)C2(C)C(OC(C)=O)C(OC(C)=O)C3=C(C)C(=O)CC(C(OC(C)=O)C12)C3(C)C |
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Safety Information
Synonyms
| 2-Propenoic acid, 3-phenyl-, (1S,3S,4aR,5R,6R,11R,12R,12aS)-1,5,11,12-tetrakis(acetyloxy)-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-9,12a,13,13-tetramethyl-4-methylene-8-oxo-6,10-methanobenzocyclodecen-3-yl ester, (2E)- |
| (2α,5α,7β,9α,10β)-2,7,9,10-tetrakis(acetyloxy)-13-oxotaxa-4(20),11-dien-5-yl (2E)-3-phenylprop-2-enoate |
| (2α,5α,7β,9α,10β)-2,7,9,10-Tetraacetoxy-13-oxotaxa-4(20),11-dien-5-yl (2E)-3-phenylacrylate |
