CAS 33627-28-0|Britannin

Introduction：Basic information about CAS 33627-28-0|Britannin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Britannin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Britannin
CAS Number	33627-28-0	Molecular Weight	366.40600
Density	1.25±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₉H₂₆O₇	Melting Point	189-191 ºC
MSDS	/	Flash Point	/

Names

Name	Britannin
Synonym	More Synonyms

Britannin BiologicalActivity

Description	Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin induces apoptosis and autophagy by activating AMPK regulated by ROS in liver cancer cells. Britannin has anti-proliferative and anti-inflammatory activities[1][2][3].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/Immunology
References	[1]. Cui YQ The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS. Biochem Biophys Res Commun. 2018 Mar 11;497(3):916-923. [2]. Park HH, et al. Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells. Int Immunopharmacol. 2013 Feb;15(2):296-302. [3]. Moghadam MH, et al. Anti-proliferative activity and apoptotic potential of britannin, a sesquiterpene lactone from Inula aucheriana. Nat Prod Commun. 2012 Aug;7(8):979-80.

Description

Britannin, isolated from Inula aucheriana, is a sesquiterpene lactone. Britannin induces apoptosis and autophagy by activating AMPK regulated by ROS in liver cancer cells. Britannin has anti-proliferative and anti-inflammatory activities[1][2][3].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/Immunology

References

[1]. Cui YQ The suppressive effects of Britannin (Bri) on human liver cancer through inducing apoptosis and autophagy via AMPK activation regulated by ROS. Biochem Biophys Res Commun. 2018 Mar 11;497(3):916-923.

[2]. Park HH, et al. Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells. Int Immunopharmacol. 2013 Feb;15(2):296-302.

[3]. Moghadam MH, et al. Anti-proliferative activity and apoptotic potential of britannin, a sesquiterpene lactone from Inula aucheriana. Nat Prod Commun. 2012 Aug;7(8):979-80.

Chemical & Physical Properties

Density	1.25±0.1 g/cm3
Melting Point	189-191 ºC
Molecular Formula	C₁₉H₂₆O₇
Molecular Weight	366.40600
Exact Mass	366.16800
PSA	99.13000
LogP	1.37450
InChIKey	JXEGMONJOSAULB-IZZBGLMFSA-N
SMILES	C=C1C(=O)OC2CC(C)C3C(OC(C)=O)CC(O)C3(C)C(OC(C)=O)C12
Water Solubility	Slightly soluble (2.7 g/L) (25 ºC)

Safety Information

Hazard Codes	Xi

Synonyms

britanin

2α,6α-diacetoxy-4β-hydroxy-11(13)-pseudoguaien-12,8α-olide

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