CAS 78574-94-4|Cycloastragenol
| Common Name | Cycloastragenol | ||
|---|---|---|---|
| CAS Number | 78574-94-4 | Molecular Weight | 490.715 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 617.2±55.0 °C at 760 mmHg |
| Molecular Formula | C30H50O5 | Melting Point | 241.0 to 245.0 °C |
| MSDS | ChineseUSA | Flash Point | 327.1±31.5 °C |
Names
| Name | Cycloastragenol |
|---|---|
| Synonym | More Synonyms |
Cycloastragenol BiologicalActivity
| Description | Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge[1].Astramembrangenin is orally safe and has broad Extensive pharmacological effects, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties[2].Astramembrangenin has antiaging properties, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Cycloastragenol (CAG) may have a novel therapeutic role in depression[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease |
| In Vitro | Astramembrangenin (0-10 µM; 3-6 days) increases cell growth compared to the vehicle control in HEK cultures[1]. Astramembrangenin (0.3 µM; 5-90 mins) induces CREB phosphorylation in primary cortical neurons, total CREB expression is unaltered by CAG in both cell type[1]. Astramembrangenin (3 µM; 6-48 hours) may promotes prosurvival signaling in neurons, increases tert mRNA expression, exhibits increased bcl2 mRNA expression[1]. Cell Viability Assay[1] Cell Line: HEK cells Concentration: 1 µM, 3 µM, 10 µM Incubation Time: 3-6 days Result: Doubled the cell growth at 6 days. Western Blot Analysis[1] Cell Line: Neuronal cells Concentration: 0.3 µM Incubation Time: 5 mins, 15 mins, 30 mins, 90 mins Result: Suggested that CAG induces CREB activation in neuronal cells. RT-PCR[1] Cell Line: Neuronal cells Concentration: 3 µM Incubation Time: 6-48 hours Result: Increased tert, bcl2 mRNA expression. |
| References | [1]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63. [2]. Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep;16(3):2175-2182. [3]. Sun C, et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):131-139. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 617.2±55.0 °C at 760 mmHg |
| Melting Point | 241.0 to 245.0 °C |
| Molecular Formula | C30H50O5 |
| Molecular Weight | 490.715 |
| Flash Point | 327.1±31.5 °C |
| Exact Mass | 490.365814 |
| PSA | 90.15000 |
| LogP | 3.82 |
| Vapour Pressure | 0.0±4.0 mmHg at 25°C |
| Index of Refraction | 1.582 |
| InChIKey | WENNXORDXYGDTP-UOUCMYEWSA-N |
| SMILES | CC(C)(O)C1CCC(C)(C2C(O)CC3(C)C4CC(O)C5C(C)(C)C(O)CCC56CC46CCC23C)O1 |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|---|
| RTECS | GX8265000 |
| HS Code | 2942000000 |
Customs
| HS Code | 2942000000 |
|---|
Articles3
More Articles| Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals 22(1) , 52-63, (2014) Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study de... | |
| A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS ONE 8(3) , e58423, (2013) The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a n... | |
| Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J. Immunol. 181(10) , 7400-6, (2008) Telomerase reverse transcribes telomere DNA onto the ends of linear chromosomes and retards cellular aging. In contrast to most normal somatic cells, which show little or no telomerase activity, immun... |
Synonyms
| 9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,9β,16β,20R,24S)- |
| Astramembrangenin |
| (3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol |
| 9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,9β,16β,20R,24R)- |
| Cycloastragenol |
| (3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol |
| Cyclosieversigenin |
| Cyclogalegigenin |
