Introduction：Basic information about CAS 180064-38-4|Minodronic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Minodronic acid |
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| CAS Number | 180064-38-4 | Molecular Weight | 322.14800 |
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| Density | 1.973 g/cm3 | Boiling Point | / |
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| Molecular Formula | C9H12N2O7P2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
Minodronic acid BiologicalActivity
| Description | Minodronic acid (YM-529) is a third-generation bisphosphonate that directly and indirectly prevents proliferation, induces apoptosis, and inhibits metastasis of various types of cancer cells. Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Membrane Transporter/Ion Channel >>P2X Receptor |
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| Target | P2X2/3[2] |
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| References | [1]. Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61. [2]. Tanaka M, et al. Minodronic acid induces morphological changes in osteoclasts at bone resorption sites and reaches a level required for antagonism of purinergic P2X2/3 receptors. J Bone Miner Metab. 2018 Jan;36(1):54-63. |
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Chemical & Physical Properties
| Density | 1.973 g/cm3 |
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| Molecular Formula | C9H12N2O7P2 |
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| Molecular Weight | 322.14800 |
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| Exact Mass | 322.01200 |
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| PSA | 172.21000 |
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| InChIKey | VMMKGHQPQIEGSQ-UHFFFAOYSA-N |
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| SMILES | O=P(O)(O)C(O)(Cc1cnc2ccccn12)P(=O)(O)O |
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| Storage condition | -20℃ |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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