Introduction：Basic information about CAS 655-05-0|Thozalinone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Thozalinone |
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| CAS Number | 655-05-0 | Molecular Weight | 204.23 |
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| Density | 1.19g/cm3 | Boiling Point | 294.8ºC at 760 mmHg |
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| Molecular Formula | C11H12N2O2 | Melting Point | 134.5ºC |
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| MSDS | / | Flash Point | 132.1ºC |
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Names
| Name | 2-(dimethylamino)-5-phenyl-1,3-oxazol-4-one |
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| Synonym | More Synonyms |
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Thozalinone BiologicalActivity
| Description | Thozalinone also known as 5phenyl-2-dimethylamino-2-oxazolin-4-one, is an excitant with activity against Tetrabenazine depression. Thozalinone has unique properties distinguishing them from the sympathomimetic amines[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| References | [1]. Greenblatt EN, et al. Some pharmacologic properties of thozalinone, a new excitant. Toxicol Appl Pharmacol. 1965 Jul;7(4):566-78. |
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Chemical & Physical Properties
| Density | 1.19g/cm3 |
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| Boiling Point | 294.8ºC at 760 mmHg |
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| Melting Point | 134.5ºC |
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| Molecular Formula | C11H12N2O2 |
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| Molecular Weight | 204.23 |
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| Flash Point | 132.1ºC |
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| Exact Mass | 204.09000 |
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| PSA | 41.90000 |
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| LogP | 0.63770 |
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| Index of Refraction | 1.584 |
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| InChIKey | JJSHYECKYLDYAR-UHFFFAOYSA-N |
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| SMILES | CN(C)C1=NC(=O)C(c2ccccc2)O1 |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- RQ5775000
- CHEMICAL NAME :
- 2-Oxazolin-4-one, 2-(dimethylamino)-5-phenyl-
- CAS REGISTRY NUMBER :
- 655-05-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C11-H12-N2-O2
- MOLECULAR WEIGHT :
- 204.25
- WISWESSER LINE NOTATION :
- T5NV DO CHJ CR& EN1&1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3000 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia Behavioral - somnolence (general depressed activity)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1240 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 570 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 250 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - ataxia
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,566,1965
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 2-Dimethylamino-5-phenyl-4-oxazolinon-(4) |
| Tozalinona [INN-Spanish] |
| 2-Oxazolin-4-one,2-(dimethylamino)-5-phenyl |
| 5-Phenyl-2-dimethylamino-2-oxazolin-4-on |
| 2-(Dimethylamino)-5-phenyl-2-oxazolin-4-one |
| 2-Dimethylamino-5-phenyl-4-oxo-2-oxazolin |
| 2-Dimethylamino-4-oxo-5-phenyl-oxazolin |
| Tozalinonum [INN-Latin] |
| Stimsen |
| 2-dimethylamino-5-phenyl-oxazol-4-one |
| Tozalinone |
| THOZALINONE |
