CAS 34316-15-9|Chelerythrine

Introduction：Basic information about CAS 34316-15-9|Chelerythrine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chelerythrine BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Chelerythrine
CAS Number	34316-15-9	Molecular Weight	348.371
Density	/	Boiling Point	/
Molecular Formula	C₂₁H₁₈ClNO₄	Melting Point	195-205ºC
MSDS	/	Flash Point	/

Names

Name	chelerythrine
Synonym	More Synonyms

Chelerythrine BiologicalActivity

Description	Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2].
Related Catalog	Signaling Pathways >>Epigenetics >>PKCResearch Areas >>CancerResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic DiseaseSignaling Pathways >>TGF-beta/Smad >>PKC
Target	PKC:0.7 μM (IC50)
References	[1]. Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9. [2]. Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91.

Chemical & Physical Properties

Melting Point	195-205ºC
Molecular Formula	C₂₁H₁₈ClNO₄
Molecular Weight	348.371
Exact Mass	348.123047
PSA	40.80000
LogP	0.72060
InChIKey	LLEJIEBFSOEYIV-UHFFFAOYSA-N
SMILES	COc1ccc2c(c[n+](C)c3c4cc5c(cc4ccc23)OCO5)c1OC
Storage condition	Desiccate at -20°C

Safety Information

Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S36/37
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

[1,3]Benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-

1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium

Cheleritrine

MFCD00060717

Chelerythrine

Chelerythrin-Kation

Chelerythrin

Chelerythrine chloride

1,2-Dimethoxy-12-methyl[1,3]dioxolo[4,5]benzo[1,2-c]phenanthridin-12-ium

Broussonpapyrine

Chelerythrin chlorid

EINECS 251-930-0

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