Introduction：Basic information about CAS 58749-22-7|Licochalcone A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Licochalcone A |
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| CAS Number | 58749-22-7 | Molecular Weight | 338.397 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 532.6±50.0 °C at 760 mmHg |
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| Molecular Formula | C21H22O4 | Melting Point | 100° |
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| MSDS | / | Flash Point | 186.9±23.6 °C |
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Names
| Name | (E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one |
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| Synonym | More Synonyms |
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Licochalcone A BiologicalActivity
| Description | Licochalcone A, a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch, presents obvious anti-cancer effects. The IC50 value is 0.97 μM for UGT1A1. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyNatural Products >>FlavonoidsResearch Areas >>Cancer |
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| References | [1]. Tang ZH, et al. Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells. Sci Rep. 2016 May 17;6:26241. [2]. Hong Xin, et al. Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases. Food and Chemical ToxicologyVolume 90, April 2016, Pages 112–122 [3]. Egler J, et al. Licochalcone A Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2015;37(5):2060-70. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 532.6±50.0 °C at 760 mmHg |
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| Melting Point | 100° |
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| Molecular Formula | C21H22O4 |
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| Molecular Weight | 338.397 |
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| Flash Point | 186.9±23.6 °C |
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| Exact Mass | 338.151794 |
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| PSA | 66.76000 |
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| LogP | 4.95 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.611 |
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| InChIKey | KAZSKMJFUPEHHW-DHZHZOJOSA-N |
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| SMILES | C=CC(C)(C)c1cc(C=CC(=O)c2ccc(O)cc2)c(OC)cc1O |
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| Storage condition | ?20°C |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 20/21/22 |
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| Safety Phrases | 36/37 |
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| RTECS | UB8755000 |
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Synonyms
| (E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one |
| Licochalcone A |
| (2E)-3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hdyroxyphenyl)-2-propen-1-one |
| LicochalconeA |
| LICOAGROCHACONE A |
| (2E)-3-[4-Hydroxy-2-methoxy-5-(2-methyl-3-buten-2-yl)phenyl]-1-(4-hydroxyphenyl)-2-propen-1-one |
| 2-Propen-1-one,3-(5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-,(E) |
| (2E)-3-[4-Hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one |
| Licochalcone-A,Synthetic |
| 5-(1,1-dimethylallyl)-4,4'-dihydroxy-2-methoxychalcone |
| (2E)-3-[5-(1,1-dimethylprop-2-en-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one |
| 3-Dimethylallyl-4,4'-dihydroxy-6-methoxychalcone |
| 2-Propen-1-one, 3-[5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-, (2E)- |
