Introduction：Basic information about CAS 58569-55-4|Met-Enkephalin acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Met-Enkephalin acetate salt |
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| CAS Number | 58569-55-4 | Molecular Weight | 573.66100 |
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| Density | 1.324 g/cm3 | Boiling Point | 1052.9ºC at 760 mmHg |
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| Molecular Formula | C27H35N5O7S | Melting Point | / |
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| MSDS | / | Flash Point | 590.6ºC |
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Names
| Name | 2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid |
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| Synonym | More Synonyms |
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Met-Enkephalin acetate salt BiologicalActivity
| Description | Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid ReceptorResearch Areas >>Neurological DiseasePeptides |
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| Target | Opioid Receptor[1]. |
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| In Vitro | Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems[1]. |
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| References | [1]. Zhao D, et al. Methionine enkephalin, its role in immunoregulation and cancer therapy. Int Immunopharmacol. 2016 Feb 23. pii: S1567-5769(16)30050-9. |
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Chemical & Physical Properties
| Density | 1.324 g/cm3 |
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| Boiling Point | 1052.9ºC at 760 mmHg |
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| Molecular Formula | C27H35N5O7S |
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| Molecular Weight | 573.66100 |
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| Flash Point | 590.6ºC |
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| Exact Mass | 573.22600 |
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| PSA | 225.25000 |
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| LogP | 1.80830 |
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| Index of Refraction | 1.608 |
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| InChIKey | YFGBQHOOROIVKG-FKBYEOEOSA-N |
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| SMILES | CSCCC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc1ccc(O)cc1)C(=O)O |
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| Storage condition | −20°C |
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Safety Information
| Safety Phrases | S22-S24/25 |
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| WGK Germany | 3 |
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Synonyms
| MET-enkephalin |
| ENKEPHALIN,METHIONINE |
| 1-5-Adrenorphin (human) |
| H-Tyr(1)-Gly(2)-Gly(3)-Phe(4)-Met(5)-OH |
| Methionine enkephalin |
| [Met5]-enkephalin |
| TYR-GLY-GLY-PHE-MET |
| Opioid growth factor |
| H-Tyr-Gly-Gly-Phe-Met-OH |
| EINECS 261-335-8 |
| Tyr-Gly-Gly-Phe-Met-OH |
| Lupex |
