CAS 776-86-3|Isoscopoletin

Introduction：Basic information about CAS 776-86-3|Isoscopoletin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Isoscopoletin BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Isoscopoletin
CAS Number	776-86-3	Molecular Weight	192.168
Density	1.4±0.1 g/cm3	Boiling Point	413.5±45.0 °C at 760 mmHg
Molecular Formula	C₁₀H₈O₄	Melting Point	206-208ºC
MSDS	/	Flash Point	172.4±22.2 °C

Names

Name	6-Hydroxy-7-methoxy-2H-chromen-2-one
Synonym	More Synonyms

Isoscopoletin BiologicalActivity

Description	Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].
Related Catalog	Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>HBV
References	[1]. Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4. [2]. Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33.

Description

Isoscopoletin (6-Hydroxy-7-methoxycoumarin) is an active constituent in Artemisia argyi leaves. Isoscopoletin shows substantial inhibition against cell proliferation, with IC50s of 4.0 μM and 1.6 μM for human CCRF-CEM leukaemia cells and multidrug resistant subline CEM/ADR5000, respectively[1]. Isoscopoletin (6-Hydroxy-7-methoxycoumarin) possesses inhibitory activity against HBV replication[2].

Related Catalog

Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Anti-infection >>HBV

References

[1]. Adams M, et al. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006 Jul;72(9):862-4.

[2]. Li H, et al. Evaluation of antiviral activity of compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus. Planta Med. 2005 Dec;71(12):1128-33.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	413.5±45.0 °C at 760 mmHg
Melting Point	206-208ºC
Molecular Formula	C₁₀H₈O₄
Molecular Weight	192.168
Flash Point	172.4±22.2 °C
Exact Mass	192.042252
PSA	59.67000
LogP	0.83
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.609
InChIKey	SYTYLPHCLSSCOJ-UHFFFAOYSA-N
SMILES	COc1cc2oc(=O)ccc2cc1O
Storage condition	2-8°C
Water Solubility	DMSO: soluble

Safety Information

Hazard Codes	Xi
Risk Phrases	R22
Safety Phrases	S22-24/25-36-26
WGK Germany	3
HS Code	29322090

Synonyms

2H-1-Benzopyran-2-one, 6-hydroxy-7-methoxy-

7-Methoxyesculetin

iso-Scopoletin

6-Hydroxy-7-methoxy-2H-chromen-2-one

6-hydroxy-7-methoxychromen-2-one

Isoscopoletin

EINECS 212-282-4

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