CAS 7758-99-8|Copper sulfate pentahydrate

CHEMICAL IDENTIFICATION

RTECS NUMBER :

GL8900000

CAS REGISTRY NUMBER :

7758-99-8

LAST UPDATED :

199712

DATA ITEMS CITED :

60

MOLECULAR FORMULA :

O4-S.Cu.5H2-O

MOLECULAR WEIGHT :

249.70

WISWESSER LINE NOTATION :

CU S-O4 &QH 5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

272 mg/kg

TOXIC EFFECTS :

Liver - jaundice (or hyperbilirubinemia) hepatocellular Kidney, Ureter, Bladder - other changes Blood - other hemolysis with or without anemia

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human

DOSE/DURATION :

1088 mg/kg

TOXIC EFFECTS :

Behavioral - coma Liver - jaundice (or hyperbilirubinemia) hepatocellular Blood - other hemolysis with or without anemia

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Human - man

DOSE/DURATION :

221 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>2 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

18700 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

33 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

60 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

62 mg/kg

TOXIC EFFECTS :

Autonomic Nervous System - other (direct) parasympathomimetic Behavioral - coma Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - pigeon

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - coma Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - duck

DOSE/DURATION :

600 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - coma Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - domestic

DOSE/DURATION :

5 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Blood - hemorrhage

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

7500 ug/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - wild bird species

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - coma Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2625 mg/kg/2W-C

TOXIC EFFECTS :

Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

24 gm/kg/13W-C

TOXIC EFFECTS :

Gastrointestinal - other changes Blood - pigmented or nucleated red blood cells Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3390 mg/kg/2W-C

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

67 gm/kg/13W-C

TOXIC EFFECTS :

Liver - changes in liver weight

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

Cytogenetic analysis

TYPE OF TEST :

Sperm Morphology

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

Micronucleus test

TYPE OF TEST :

Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :

Bird - chicken

DOSE/DURATION :

7500 ug/kg

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 367,57,1996 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993 OEL-AUSTRALIA:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993 OEL-AUSTRALIA:TWA 1 mg(Cu)/m3 (dust) JAN 1993 OEL-BELGIUM:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993 OEL-BELGIUM:TWA 1 mg(Cu)/m3 (dust) JAN 1993 OEL-DENMARK:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993 OEL-DENMARK:TWA 1 mg(Cu)/m3 (dust) JAN 1993 OEL-FINLAND:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993 OEL-FINLAND:TWA 1 mg(Cu)/m3 (dust) JAN 1993 OEL-FRANCE:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993 OEL-FRANCE:TWA 1 mg(Cu)/m3;STEL 2 mg(Cu)/m3 (dust) JAN 1993 OEL-GERMANY:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993 OEL-GERMANY:TWA 1 mg(Cu)/m3 (dust) JAN 1993 OEL-HUNGARY:TWA 0.2 mg(Cu)/m3;STEL 0.4 mg(Cu)/m3 (dust) JAN 1993 OEL-INDIA:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993 OEL-THE NETHERLANDS:TWA 02 mg(Cu)/m3 (fume) JAN 1993 OEL-THE NETHERLANDS:TWA 1 mg(Cu)/m3 (dust) JAN 1993 OEL-THE PHILIPPINES:TWA 1.0 mg(Cu)/m3 (fume) JAN 1993 OEL-POLAND:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993 OEL-RUSSIA:STEL 0.5 ppm (1 mg(Cu)/m3) (dust) JAN 1993 OEL-SWEDEN:TWA 0.2 mg(Cu)/m3 (resp. dust) JAN 1993 OEL-SWEDEN:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993 OEL-SWEDEN:TWA 1 mg(Cu)/m3 (total dust) JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Cu)/m3;STEL 0.2 mg(Cu)/m3 (fume) JAN 1993 OEL-SWITZERLAND:TWA 1 mg(Cu)/m3;STEL 1 mg(Cu)/m3 JAN 1993 OEL-THAILAND:TWA 0.1 mg(Cu)/m3 (fume) JAN 1993 OEL-THAILAND:TWA 1 mg(Cu)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg(Cu)/m3 (fume) JAN 1993 OEL-UNITED KINGDOM:TWA 1 mg(Cu)/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5421 No. of Facilities: 979 (estimated) No. of Industries: 13 No. of Occupations: 21 No. of Employees: 10821 (estimated) No. of Female Employees: 3606 (estimated)

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