CAS 58-63-9|Inosine
Introduction：Basic information about CAS 58-63-9|Inosine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Inosine | ||
|---|---|---|---|
| CAS Number | 58-63-9 | Molecular Weight | 268.226 |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 670.5±65.0 °C at 760 mmHg |
| Molecular Formula | C10H12N4O5 | Melting Point | 222-226 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 359.3±34.3 °C |
Names
| Name | inosine |
|---|---|
| Synonym | More Synonyms |
Inosine BiologicalActivity
| Description | Inosine, an endogenous purine nucleoside, has immunomodulatory, neuroprotective, and analgesic properties. In vitro: Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] In vivo: The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2] |
|---|---|
| Related Catalog | Natural Products >>OthersResearch Areas >>Others |
| Target | Human Endogenous Metabolite |
| References | [1]. Moore TL et al. Inosine enhances recovery of grasp following cortical injury to the primary motor cortex of the rhesus monkey. Restor Neurol Neurosci. 2016 Aug 1. [2]. Welihinda AA et al. The adenosine metabolite inosine is a functional agonist of the adenosine A2A receptor with a unique signaling bias. Cell Signal. 2016 Jun;28(6):552-60. [3]. Junqueira SC et al. Inosine, an Endogenous Purine Nucleoside, Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis: a Role for A2A Adenosine Receptor. Mol Neurobiol. 2016 Apr 30. |
Chemical & Physical Properties
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 670.5±65.0 °C at 760 mmHg |
| Melting Point | 222-226 °C (dec.)(lit.) |
| Molecular Formula | C10H12N4O5 |
| Molecular Weight | 268.226 |
| Flash Point | 359.3±34.3 °C |
| Exact Mass | 268.080780 |
| PSA | 133.49000 |
| LogP | -1.91 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.879 |
| Water Solubility | 2.1 g/100 mL (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2900 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >20 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3175 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >2800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 558 gm/kg/93D-C
- TOXIC EFFECTS :
- Endocrine - changes in thymus weight Blood - normocytic anemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
MUTATION DATA - TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 60 mmol/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4726 No. of Facilities: 121 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1253 (estimated) No. of Female Employees: 904 (estimated)
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 60 mmol/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4726 No. of Facilities: 121 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1253 (estimated) No. of Female Employees: 904 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | NM7460000 |
| HS Code | 2934999090 |
Customs
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 6-Oxopurine riboside |
| HXR |
| RIBOXINE |
| nosine |
| Ino |
| EINECS 200-390-4 |
| 9-β-δ-Ribofuranosylhypoxanthine |
| Hypoxanthine, 9-β-D-ribofuranosyl- |
| 1,9-dihydro-9-b-D-ribofuranosyl-6H-Purin-6-one |
| 9-β-D-ribofuranosyl-Hypoxanthine |
| 9-β-D-Ribofuranosylhypoxanthine |
| Inosie |
| 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxyméthyl)tétrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one |
| INO 495 |
| hypoxanthine |
| Oxiamin |
| 9-b-D-Ribofuranosylhypoxanthine |
| Atorel |
| MFCD00066770 |
| 6H-Purin-6-one, 1,9-dihydro-9-β-D-ribofuranosyl- |
| 9β-D-Ribofuranosylhypoxanthine |
| 6-oxy-purine riboside |
| 9H-Purin-6-ol, 9-β-D-ribofuranosyl- |
| 9-β-D-ribofuranosyl-1,9-dihydro-6H-purin-6-one |
| 9-b-D-ribofuranosyl-Hypoxanthine |
| Inosine |
| 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,9-dihydro-6H-purin-6-one |
| T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q &&β-D-Ribo Form |
| Inosine (8CI,9CI) |
| Selfer |
