Introduction：Basic information about CAS 82-92-8|Cyclizine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cyclizine |
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| CAS Number | 82-92-8 | Molecular Weight | 266.38100 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C18H22N2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | cyclizine |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Molecular Formula | C18H22N2 |
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| Molecular Weight | 266.38100 |
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| Exact Mass | 266.17800 |
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| PSA | 6.48000 |
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| LogP | 2.89920 |
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| InChIKey | UVKZSORBKUEBAZ-UHFFFAOYSA-N |
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| SMILES | CN1CCN(C(c2ccccc2)c2ccccc2)CC1 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- TL6475000
- CHEMICAL NAME :
- Piperazine, 1-(diphenylmethyl)-4-methyl-
- CAS REGISTRY NUMBER :
- 82-92-8
- BEILSTEIN REFERENCE NO. :
- 0230441
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C18-H22-N2
- MOLECULAR WEIGHT :
- 266.42
- WISWESSER LINE NOTATION :
- T6N DNTJ AYR&R& D1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 126 mg/kg/6W-I
- TOXIC EFFECTS :
- Blood - agranulocytosis
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 292,174,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 147 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,218,1972 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 450 mg/kg
- SEX/DURATION :
- female 10-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,323,1970
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 450 mg/kg
- SEX/DURATION :
- female 10-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Effects on Newborn - stillbirth
- REFERENCE :
- BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 109,323,1970 *** REVIEWS *** TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966
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Safety Information
| Hazard Codes | T+ |
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| HS Code | 2933599090 |
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Customs
| HS Code | 2933599090 |
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| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Ciclizina |
| Marzine |
| N-benzhydryl-N'-methylpiperazine |
| Valoid |
| Bw 47-83 |
| Marazine |
| 1-Benzhydryl-4-methyl-piperazin |
| Emoquil |
| Nautazine |
| Marezine |
| Wellcome |
| CYCLIZINE HCL |
| 1-diphenylmethyl-4-methylpiperazine |
| 1-benzhydryl-4-methyl-piperazine |
