Introduction：Basic information about CAS 187223-15-0|Fmoc-Hyp(Bom)-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Fmoc-Hyp(Bom)-OH |
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| CAS Number | 187223-15-0 | Molecular Weight | 539.577 |
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| Density | 1.35±0.1 g/cm3 | Boiling Point | 749.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C28H33N3O8 | Melting Point | / |
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| MSDS | / | Flash Point | 406.8±32.9 °C |
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Names
| Name | fmoc-l-hyp(bom)-oh |
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| Synonym | More Synonyms |
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Fmoc-Hyp(Bom)-OH BiologicalActivity
| Description | Fmoc-Hyp(Bom)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Hyp(Bom)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]< |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.35±0.1 g/cm3 |
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| Boiling Point | 749.0±60.0 °C at 760 mmHg |
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| Molecular Formula | C28H33N3O8 |
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| Molecular Weight | 539.577 |
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| Flash Point | 406.8±32.9 °C |
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| Exact Mass | 539.226746 |
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| PSA | 143.50000 |
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| LogP | 3.54 |
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| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
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| Index of Refraction | 1.620 |
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| InChIKey | PFVAFJSUWCTINJ-HXOBKFHXSA-N |
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| SMILES | CC(C)(C)OC(=O)NCCNC(=O)OC1CC(C(=O)O)N(C(=O)OCC2c3ccccc3-c3ccccc32)C1 |
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| Water Solubility | Insuluble (1.5E-3 g/L) (25 ºC) |
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Synonyms
| 1,2-Pyrrolidinedicarboxylic acid, 4-[[[[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]amino]carbonyl]oxy]-, 1-(9H-fluoren-9-ylmethyl) ester, (2S,4R)- |
| 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-({[2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)ethyl]carbamoyl}oxy)proline |
| Fmoc-(2S,4R)-Pro(4-OCO-NH-CH2-CH2-NH-Boc)-OH |
| 1,2-Pyrrolidinedicarboxylic acid, 4-[[[[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]amino]carbonyl]oxy]-, 1-(9H-fluoren-9-ylmethyl) ester |
| (4R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-({[2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)ethyl]carbamoyl}oxy)-L-proline |
| Fmoc-Hyp(Bcc)-OH |
| Fmoc-(2S,4R)-(4-OCO-NH-CH2-CH2-NH-Boc)-Pro-OH |
| (2S,4R)-4-[[[[2-[[(1,1-Dimethylethoxy)carbonyl]amino]ethyl]amino]carbonyl]oxy]-1,2-pyrrolidinedicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester |
| Fmoc-Hyp(Bom)-OH |
