CAS 78957-84-3|Calmodulin antagonist-1

Introduction：Basic information about CAS 78957-84-3|Calmodulin antagonist-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Calmodulin antagonist-1 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Synonyms

Common Name	Calmodulin antagonist-1
CAS Number	78957-84-3	Molecular Weight	349.28
Density	/	Boiling Point	501.5ºC at 760 mmHg
Molecular Formula	C₁₄H₁₈Cl₂N₂O₂S	Melting Point	243-246ºC
MSDS	/	Flash Point	257.1ºC

Names

Name	N-(4-aminobutyl)-5-chloronaphthalene-1-sulfonamide,hydrochloride
Synonym	More Synonyms

Calmodulin antagonist-1 BiologicalActivity

Description	Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=28 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=375 μM) in a competitive fashion with respect to cyclic GMP and the Ki value is 300 μM[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Neuronal Signaling >>CaMK
References	[1]. Itoh H, et al. Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J Biochem. 1984;96(6):1721-1726.

Chemical & Physical Properties

Boiling Point	501.5ºC at 760 mmHg
Melting Point	243-246ºC
Molecular Formula	C₁₄H₁₈Cl₂N₂O₂S
Molecular Weight	349.28
Flash Point	257.1ºC
Exact Mass	348.046600
PSA	80.57000
LogP	5.48440
InChIKey	IKMXJMNRHREPOD-UHFFFAOYSA-N
SMILES	Cl.NCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12

Safety Information

HS Code	2935009090

Customs

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Synonyms

1-Butanaminium, 4-[[(5-chloro-1-naphthalenyl)sulfonyl]amino]-, chloride (1:1)

N-(4-Aminobutyl)-5-chloronaphthalene-1-sulfonamide hydrochloride (1:1)

N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride

4-{[(5-Chloro-1-naphthyl)sulfonyl]amino}-1-butanaminium chloride

N-(4-Aminobutyl)-5-chloro-1-naphthalenesulphonamide hydrochloride

OR0190T

Calmodulin antagonist-1

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