CAS 34114-99-3|T-2 Tetraol

Introduction：Basic information about CAS 34114-99-3|T-2 Tetraol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. T-2 Tetraol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles17
7. Synonyms

Common Name	T-2 Tetraol
CAS Number	34114-99-3	Molecular Weight	298.332
Density	1.5±0.1 g/cm3	Boiling Point	515.2±50.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₂O₆	Melting Point	125°C- 135 °C
MSDS	/	Flash Point	265.4±30.1 °C
Symbol	GHS02, GHS07	Signal Word	Danger

Names

Name	t-2 tetraol
Synonym	More Synonyms

T-2 Tetraol BiologicalActivity

Description	T-2 Tetraol is a metabolite of T-2 toxin, and also a trichothecene mycotoxin, with less toxicity and is unable to induce apoptosis[1][2].
Related Catalog	Research Areas >>OthersSignaling Pathways >>Others >>Others
References	[1]. Engler KH, et al. A colorimetric technique for detecting trichothecenes and assessing relative potencies. Appl Environ Microbiol. 1999 May;65(5):1854-7. [2]. Islam Z, et al. Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice. Biosci Biotechnol Biochem. 1998 Aug;62(8):1492-7.

Description

T-2 Tetraol is a metabolite of T-2 toxin, and also a trichothecene mycotoxin, with less toxicity and is unable to induce apoptosis[1][2].

Related Catalog

Research Areas >>OthersSignaling Pathways >>Others >>Others

References

[1]. Engler KH, et al. A colorimetric technique for detecting trichothecenes and assessing relative potencies. Appl Environ Microbiol. 1999 May;65(5):1854-7.

[2]. Islam Z, et al. Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice. Biosci Biotechnol Biochem. 1998 Aug;62(8):1492-7.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	515.2±50.0 °C at 760 mmHg
Melting Point	125°C- 135 °C
Molecular Formula	C₁₅H₂₂O₆
Molecular Weight	298.332
Flash Point	265.4±30.1 °C
Exact Mass	298.141632
PSA	102.68000
LogP	-0.77
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.644
InChIKey	ZAXZBJSXSOISTF-VREARNNESA-N
SMILES	CC1=CC2OC3C(O)C(O)C(C)(C2(CO)CC1O)C31CO1
Storage condition	−20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YC9980000

CHEMICAL NAME :: Trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol, 12,13-epoxy-

CAS REGISTRY NUMBER :: 34114-99-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H22-O6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 36900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 26,923,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 184 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Behavioral - ataxia

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 26,923,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 24,985,1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DFSCDX Developments in Food Science. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1978- Volume(issue)/page/year: 4,135,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 25,335,1983

Safety Information

Symbol	GHS02, GHS07
Signal Word	Danger
Hazard Statements	H225-H302 + H312 + H332-H319
Precautionary Statements	P210-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T+: Very toxic;
Risk Phrases	26/27/28-36/37/38
Safety Phrases	22-36/37/39-45
RIDADR	UN2811 6.1/PG 1
RTECS	YC9980000

Articles17

Occurrence and distribution of 13 trichothecene toxins in naturally contaminated maize plants in Germany.

Toxins (Basel.) 4(10) , 778-87, (2012)

The objective of the present study was to monitor the occurrence and distribution of a spectrum of trichothecene toxins in different parts of maize plants. Therefore maize plants were sampled randomly...

The natural occurrence of T-2 toxin and fumonisins in maize samples in Croatia.

Bull. Environ. Contam. Toxicol. 88(6) , 863-6, (2012)

Maize (Zea mays) considered to be one of the most frequent crops in Croatia, is often contaminated with Fusarium mycotoxins. The aim of this study was to investigate the possible contamination of maiz...

Production of T-2 toxin and related trichothecenes on different media.

Acta Vet. Hung. 32(3-4) , 147-52, (1984)

Synonyms

T-4 toxin

(3β,4α,8α,12ξ)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol

Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, (2α,3α,4β,6β,8β,11β,12ξ)-

t-2toxintetraol

t-2tetraol

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CAS 34114-99-3|T-​2 Tetraol