CAS 346451-15-8|Cetirizine Impurity D

Introduction：Basic information about CAS 346451-15-8|Cetirizine Impurity D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Cetirizine Impurity D BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Cetirizine Impurity D
CAS Number	346451-15-8	Molecular Weight	560.38500
Density	/	Boiling Point	270-275℃(Press: 1 Torr)
Molecular Formula	C₃₀H₃₀Cl₄N₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	1,4-bis[(4-chlorophenyl)-phenylmethyl]piperazine,dihydrochloride
Synonym	More Synonyms

Cetirizine Impurity D BiologicalActivity

Description	Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
Related Catalog	Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>EndocrinologyResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor
References	[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055-1080, 1993. [2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.

Description

Cetirizine Impurity D is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].

Related Catalog

Signaling Pathways >>Immunology/Inflammation >>Histamine ReceptorResearch Areas >>EndocrinologyResearch Areas >>Inflammation/ImmunologySignaling Pathways >>GPCR/G Protein >>Histamine Receptor

References

[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055-1080, 1993.

[2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5.

[3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.

Chemical & Physical Properties

Boiling Point	270-275℃(Press: 1 Torr)
Molecular Formula	C₃₀H₃₀Cl₄N₂
Molecular Weight	560.38500
Exact Mass	558.11600
PSA	6.48000
LogP	8.96980
InChIKey	DLEQNCKNBPYHEY-UHFFFAOYSA-N
SMILES	Cl.Cl.Clc1ccc(C(c2ccccc2)N2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)cc1

Synonyms

MFCD03844641

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