CAS 65240-86-0|PPM-18

Introduction：Basic information about CAS 65240-86-0|PPM-18, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. PPM-18 BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	PPM-18
CAS Number	65240-86-0	Molecular Weight	277.274
Density	1.4±0.1 g/cm3	Boiling Point	517.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₁NO₃	Melting Point	/
MSDS	/	Flash Point	208.2±30.3 °C

Names

Name	N-(1,4-dioxonaphthalen-2-yl)benzamide
Synonym	More Synonyms

PPM-18 BiologicalActivity

Description	PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter[1]. PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways[2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/Immunology
References	[1]. S M Yu, et al. Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):363-9. [2]. Huiai Lu, et al. PPM-18, an Analog of Vitamin K, Induces Autophagy and Apoptosis in Bladder Cancer Cells Through ROS and AMPK Signaling Pathways. Front Pharmacol. 2021 Jul 9;12:684915.

Description

PPM-18 (NSC 73233), a potent anti-inflammatory agent, inhibits nitric oxide synthase expression. PPM-18 is a potent inhibitor of iNOS expression by blocking the binding of NF-κB to promoter[1]. PPM-18, an analog of Vitamin K, induces autophagy and apoptosis in bladder cancer cells through ROS and AMPK signaling pathways[2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Inflammation/Immunology

References

[1]. S M Yu, et al. Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):363-9.

[2]. Huiai Lu, et al. PPM-18, an Analog of Vitamin K, Induces Autophagy and Apoptosis in Bladder Cancer Cells Through ROS and AMPK Signaling Pathways. Front Pharmacol. 2021 Jul 9;12:684915.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	517.5±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₁NO₃
Molecular Weight	277.274
Flash Point	208.2±30.3 °C
Exact Mass	277.073883
PSA	63.24000
LogP	2.09
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.667

Synonyms

Benzamide, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-

2-benzoylamino-1,4-naphthoquinone

ppm-18

N-(1,4-Dioxo-1,4-dihydro-2-naphthalenyl)benzamide

2-Benzamino-1,4-naphthochinon

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