CAS 5852-78-8|5-Carboxy-8-hydroxyquinoline
| Common Name | 5-Carboxy-8-hydroxyquinoline | ||
|---|---|---|---|
| CAS Number | 5852-78-8 | Molecular Weight | 189.167 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 464.5±30.0 °C at 760 mmHg |
| Molecular Formula | C10H7NO3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 234.7±24.6 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 8-hydroxyquinoline-5-carboxylic acid |
|---|---|
| Synonym | More Synonyms |
5-Carboxy-8-hydroxyquinoline BiologicalActivity
| Description | IOX1 is the most potent broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases; IC50 for KDM4A/KDM3A is 0.6/0.1 uM.IC50 value: 0.6/0.1 uM(KDM4A/KDM3A) [1]Target: JmjC KDMs inhibitorIOX1 is the most potent against a representative panel of 2OG oxygenases, including non-JmjC 2OG oxygenases, with an in vitro IC50 value in the micromolar range. However, its efficacy in cells is about a hundred-fold lower (HeLa cells, KDM4A, IC50 = 86uM), possibly due to low cell permeability resulting from itspolar C-5 carboxyl group. |
|---|---|
| Related Catalog | Signaling Pathways >>Epigenetics >>Histone DemethylaseResearch Areas >>Cancer |
| References | [1]. Schiller R, et al. A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1. ChemMedChem. 2014 Mar;9(3):566-71. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 464.5±30.0 °C at 760 mmHg |
| Molecular Formula | C10H7NO3 |
| Molecular Weight | 189.167 |
| Flash Point | 234.7±24.6 °C |
| Exact Mass | 189.042587 |
| PSA | 70.42000 |
| LogP | 1.81 |
| Appearance of Characters | white to brown |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.730 |
| InChIKey | JGRPKOGHYBAVMW-UHFFFAOYSA-N |
| SMILES | O=C(O)c1ccc(O)c2ncccc12 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble10mg/mL, clear |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933499090 |
Customs
| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles3
More Articles| Kdm3a lysine demethylase is an Hsp90 client required for cytoskeletal rearrangements during spermatogenesis. Mol. Biol. Cell 25(8) , 1216-33, (2014) The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required for male fertility, sex determination, and metabolic homeostasis through its nuclear role in chromatin remodeling. Many histone-modifying enzy... | |
| IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteins. Int. J. Mol. Med. 37 , 189-96, (2015) The epigenetic modification of vascular smooth muscle cell (VSMC) phenotypic switching, proliferation, migration, apoptosis and extracellular matrix synthesis is known to occur in atherosclerosis. The... | |
| A scintillation proximity assay for histone demethylases. Anal. Biochem. 463 , 54-60, (2014) Covalent modifications, such as methylation and demethylation of lysine residues in histones, play important roles in chromatin dynamics and the regulation of gene expression. The lysine demethylases ... |
Synonyms
| 8XQ |
| 8-Hydroxy-chinolin-5-carbonsaeure |
| 5-Quinolinecarboxylic acid, 8-hydroxy- |
| 8-hydroxy-quinoline-5-carboxylic acid |
| UNII-JM015YQC1C |
| 5-Carboxy-8-hydroxyquinoline |
| IOX1 |
| 8-Hydroxy-5-quinolinecarboxylic acid |
