CAS 972-02-1|Difenidol
Introduction：Basic information about CAS 972-02-1|Difenidol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Difenidol | ||
|---|---|---|---|
| CAS Number | 972-02-1 | Molecular Weight | 309.44500 |
| Density | 1.066 g/cm3 | Boiling Point | 473.3ºC at 760 mmHg |
| Molecular Formula | C21H27NO | Melting Point | 105ºC |
| MSDS | / | Flash Point | 233.5ºC |
Names
| Name | diphenidol |
|---|---|
| Synonym | More Synonyms |
Difenidol BiologicalActivity
| Description | Diphenidol is an orally active antiemetic. Diphenidol reduces abnormal neuropathic pain and TNF-α overexpression in rats following chronic compression injury. Diphenidol also has local anaesthetic activity and inhibits sodium currents. Diphenidol can be used in studies of meniere′s disease, anti-vertigo, antiemetic and analgesia[1][2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
| In Vitro | Diphenidol (0.1-100 µM) blocks Na+ currents with an IC50 of 0.77 µM and a Hill coefficient of 1.15 in N2A cells[1]. |
| In Vivo | Diphenidol (0.77 mg/rat; intrathecal injection; single) blocks motor function, proprioception, and nociception in rats[1]. Diphenidol (0.62, 3.09 mg/kg; i.p.; single daily for 7 days) effectively reverses or completely blocks CCI-evoked mechanical allodynia in rats[2]. Animal Model: Male SpragueeDawley rats (275-325 g)[1]. Dosage: 0.77 mg/rat (2.50 µmol/rat) Administration: Intrathecal injection; single. Result: Caused 100% of blockades in motor function, proprioception, and nociception with durations of action of about 51, 77, and 123 min, respectively. Animal Model: Male adult Sprague-Dawley rats (200-250 g; CCI rat model)[2]. Dosage: 0.62, 3.09 mg/kg (2, 10 µmol/kg) Administration: Intraperitoneal injection; single daily for 7 days. Result: Blocked the CCI-induced low mechanical withdrawal threshold at 1 h after administration. Reduced the level of TNF-α on day 7 and alleviated neuropathic tactile allodynia following CCI in rats. |
Chemical & Physical Properties
| Density | 1.066 g/cm3 |
|---|---|
| Boiling Point | 473.3ºC at 760 mmHg |
| Melting Point | 105ºC |
| Molecular Formula | C21H27NO |
| Molecular Weight | 309.44500 |
| Flash Point | 233.5ºC |
| Exact Mass | 309.20900 |
| PSA | 23.47000 |
| LogP | 4.12650 |
| Index of Refraction | 1.5614 (estimate) |
| InChIKey | OGAKLTJNUQRZJU-UHFFFAOYSA-N |
| SMILES | OC(CCCN1CCCCC1)(c1ccccc1)c1ccccc1 |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 815 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 5,265,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 304 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 450 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 5,265,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 103 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- LACHDL Liebigs Annalen der Chemie. (Verlag Chemie International, Inc., VCH Pub., Inc., 303 N.W. 12th Ave., Deerfield Beach, FL 33441) No. 1- 1979- Volume(issue)/page/year: (10),1554,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 13,325,1965
Safety Information
| HS Code | 2933399090 |
|---|
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Synonyms
| Difenidol |
| 1,1-diphenyl-4-piperidylbutanol |
| Vontrol |
| Nometic |
| 1,1-diphenyl-4-piperidin-1-ylbutan-1-ol |
| DIPHENIDOL |
| defenidol |
| Difenidolo [DCIT] |
| Difenidolo |
| Cephadol |
| Difenidolum |
| Avomol |
| 1,1-diphenyl-4-piperidin-1-yl-butan-1-ol |
