Introduction：Basic information about CAS 272105-42-7|Disitertide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Disitertide |
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| CAS Number | 272105-42-7 | Molecular Weight | 1580.82000 |
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| Density | 1.327g/cm3 | Boiling Point | 1968.718ºC at 760 mmHg |
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| Molecular Formula | C68H109N17O22S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Disitertide |
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| Synonym | More Synonyms |
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Disitertide BiologicalActivity
| Description | Disitertide is an inhibitor of TGF-β1. Sequence: Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>TGF-beta/SmadSignaling Pathways >>TGF-beta/Smad >>TGF-beta/SmadResearch Areas >>CancerPeptidesPeptides |
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| In Vitro | Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1]. |
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| In Vivo | Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1]. |
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| References | [1]. Ezquerro IJ et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine. 2003 Apr;22(1-2):12-20. |
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Chemical & Physical Properties
| Density | 1.327g/cm3 |
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| Boiling Point | 1968.718ºC at 760 mmHg |
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| Molecular Formula | C68H109N17O22S2 |
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| Molecular Weight | 1580.82000 |
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| Exact Mass | 1579.74000 |
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| PSA | 692.18000 |
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| LogP | 1.27260 |
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| InChIKey | IUYPEUHIWDMJLM-SWHDLQTQSA-N |
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| SMILES | CCC(C)C(NC(=O)C(CO)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(N)C(C)O)C(=O)NC(C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(C)C(=O)NC(CCSC)C(=O)NC(CCSC)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)O)C(C)CC |
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| Storage condition | -20°C |
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Synonyms
