Introduction：Basic information about CAS 18621-18-6|Azetidin-3-ol hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Azetidin-3-ol hydrochloride |
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| CAS Number | 18621-18-6 | Molecular Weight | 109.555 |
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| Density | / | Boiling Point | 170.7ºC at 760 mmHg |
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| Molecular Formula | C3H8ClNO | Melting Point | 90-92°C |
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| MSDS | ChineseUSA | Flash Point | 120.4ºC |
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| Symbol |
GHS05, GHS07 | Signal Word | Danger |
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Names
| Name | azetidin-3-ol,hydrochloride |
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| Synonym | More Synonyms |
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Azetidin-3-ol hydrochloride BiologicalActivity
| Description | Azetidin-3-ol hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azetidin-3-ol hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthes PROTAC. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Boiling Point | 170.7ºC at 760 mmHg |
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| Melting Point | 90-92°C |
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| Molecular Formula | C3H8ClNO |
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| Molecular Weight | 109.555 |
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| Flash Point | 120.4ºC |
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| Exact Mass | 109.029442 |
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| PSA | 32.26000 |
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| LogP | 0.08130 |
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| Vapour Pressure | 0.464mmHg at 25°C |
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| InChIKey | UQUPQEUNHVVNKW-UHFFFAOYSA-N |
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| SMILES | Cl.OC1CNC1 |
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| Storage condition | Room temperature. |
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Safety Information
| Symbol |
GHS05, GHS07 |
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| Signal Word | Danger |
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| Hazard Statements | H302-H315-H318-H335 |
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| Precautionary Statements | P261-P280-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | C,Xi,Xn |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26-S36/37/39 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Articles1
More Articles
Org. Process Res. Dev. 10 , 803, (2006)
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Synonyms
| 3-Azetidinol Hydrochloride |
| azetidin-3-ol monohydrochloride |
| MFCD02683887 |
| Azetidin-3-ol hydrochloride |
| 3-hydroxyazetidine monohydrochloride |
| 3-Hydroxyazetidine-HCl |
| azetidin-3-ol-hydrochloride |
| 3-Azetidinol hydrochloride (1:1) |
| 3-Azetidinol, hydrochloride (1:1) |
| 3-hydroxy-1-azetidine hydrochloride |
| azetidin-3-ol hcl |
| 3-Hydroxyazetidine Hydrochloride |
| 3-hydroxyazetidinium chloride |
| 3 HYDROXY AZETIDINE HYDROCHLORIDE |
