Introduction：Basic information about CAS 18490-95-4|Brevifolincarboxylic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Brevifolincarboxylic acid |
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| CAS Number | 18490-95-4 | Molecular Weight | 292.198 |
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| Density | 2.0±0.1 g/cm3 | Boiling Point | 758.5±60.0 °C at 760 mmHg |
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| Molecular Formula | C13H8O8 | Melting Point | 250 °C |
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| MSDS | / | Flash Point | 296.2±26.4 °C |
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Names
| Name | brevifolin carboxylic acid |
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| Synonym | More Synonyms |
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Brevifolincarboxylic acid BiologicalActivity
| Description | Brevifolincarboxylic acid is extracted from Polygonum capitatum[1], has inhibitory effect on the aryl hydrocarbon receptor (AhR)[2]. Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM[3]. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Aryl Hydrocarbon ReceptorResearch Areas >>Inflammation/ImmunologyResearch Areas >>Metabolic Disease |
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| Target | IC50: 323.46 μM (α-glucosidase) (Brevifolincarboxylic acid)[3] |
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| References | [1]. Chen X, et al. Simultaneous isolation and purification of gallic acid and brevifolincarboxylic acid from Polygonum capitatum by high-speed counter-current chromatography. Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(15):1957-60. [2]. Amakura Y, et al. Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biol Pharm Bull. 2003 Dec; 26(12):1754-60. [3]. Liu M, et al. Separation of α-glucosidase inhibitors from Potentilla kleiniana Wight et Arn using solvent and flow-rate gradient high-speed counter-current chromatography target-guided by ultrafiltration HPLC-MS screening. Phytochem Anal. 2019 May 6. |
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Chemical & Physical Properties
| Density | 2.0±0.1 g/cm3 |
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| Boiling Point | 758.5±60.0 °C at 760 mmHg |
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| Melting Point | 250 °C |
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| Molecular Formula | C13H8O8 |
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| Molecular Weight | 292.198 |
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| Flash Point | 296.2±26.4 °C |
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| Exact Mass | 292.021912 |
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| PSA | 145.27000 |
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| LogP | 0.99 |
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| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
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| Index of Refraction | 1.802 |
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| InChIKey | JFJWMFPFMLRLMI-UHFFFAOYSA-N |
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| SMILES | O=C1CC(C(=O)O)c2c1oc(=O)c1cc(O)c(O)c(O)c21 |
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Synonyms
| Benzo[d]cyclopenta[b]pyran-1-carboxylic acid, 1,2,3,5-tetrahydro-7,8,9-trihydroxy-3,5-dioxo- |
| brevifolincarboxylic acid |
| 7,8,9-Trihydroxy-3,5-dioxo-1,2,3,5-tetrahydrocyclopenta[c]isochromene-1-carboxylic acid |
