CAS 7400-08-0|p-Hydroxy-cinnamic acid

Introduction：Basic information about CAS 7400-08-0|p-Hydroxy-cinnamic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. p-Hydroxy-cinnamic acid BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	p-Hydroxy-cinnamic acid
CAS Number	7400-08-0	Molecular Weight	164.158
Density	1.3±0.1 g/cm3	Boiling Point	346.1±17.0 °C at 760 mmHg
Molecular Formula	C₉H₈O₃	Melting Point	212-214ºC
MSDS	/	Flash Point	177.3±17.4 °C

Names

Name	4-coumaric acid
Synonym	More Synonyms

p-Hydroxy-cinnamic acid BiologicalActivity

Description	p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Prostaglandin ReceptorNatural Products >>Acids and AldehydesResearch Areas >>Others
Target	PGE2:126 μM (IC50) TXB2:371 μM (IC50) Human Endogenous Metabolite
In Vitro	p-Hydroxycinnamic acid (p-Coumaric acid), is a ubiquitous plant metabolite with antioxidant and anti-inflammatory properties. p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55•2 (SE 4•01) % and 35•6 (SE 2•35) % relative to basal level, respectively). p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary haemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively)[1].
References	[1]. Luceri C, et al. p-Coumaric acid, a common dietary phenol, inhibits platelet activity in vitro and in vivo. Br J Nutr. 2007 Mar;97(3):458-63.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	346.1±17.0 °C at 760 mmHg
Melting Point	212-214ºC
Molecular Formula	C₉H₈O₃
Molecular Weight	164.158
Flash Point	177.3±17.4 °C
Exact Mass	164.047348
PSA	57.53000
LogP	1.88
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.660
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD9094000

CHEMICAL NAME :: Cinnamic acid, p-hydroxy-

CAS REGISTRY NUMBER :: 7400-08-0

BEILSTEIN REFERENCE NO. :: 2207383

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C9-H8-O3

MOLECULAR WEIGHT :: 164.17

WISWESSER LINE NOTATION :: QV1U1R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 657 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 104,793,1984 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2800 mg/kg

SEX/DURATION :: male 56 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 23,677,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 35 mg/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 16,1285,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 20,49,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 9600 mg/kg

SEX/DURATION :: female 12 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 195,575,1977

Safety Information

Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S22-S26-S36/37/39
WGK Germany	2
RTECS	GD9095000

Synonyms

p-Hydroxycinnamic acid

b-[4-Hydroxyphenyl]acrylic Acid

E-4-HydroxycinnamicAcid

2-Propenoic acid, 3-(4-hydroxyphenyl)-, (2E)-

4-Coumaric acid

4-Hydroxycinnamic acid

p-Hydroxycinnamic acid, trans

2-Propenoic acid, 3- (4-hydroxyphenyl)-

(2E)-3-(4-Hydroxyphenyl)acrylic acid

(E)-4-Hydroxycinnamic acid

EINECS 231-000-0

trans-p-hydroxycinnamic acid

PARA-HYDROXYCINNAMIC ACID

p-coumaric acid

hydroxycinnamic acid

p-Coumaric acid, trans

trans-4-hydroxycinnamic acid

trans-4-coumaric acid

trans-p-Coumaric Acid

(2E)-3-(4-hydroxyphenyl)prop-2-enoic acid

β-[4-hydroxyphenyl]acrylic acid

p-Hydroxy-cinnamic acid

(E)-p-hydroxycinnamic acid

β-(4-Hydroxyphenyl)acrylic acid

MFCD00004399

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