Introduction：Basic information about CAS 497-76-7|Arbutin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Arbutin |
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| CAS Number | 497-76-7 | Molecular Weight | 272.251 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 561.6±50.0 °C at 760 mmHg |
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| Molecular Formula | C12H16O7 | Melting Point | 195-198 °C |
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| MSDS | ChineseUSA | Flash Point | 293.4±30.1 °C |
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Names
| Name | hydroquinone O-β-D-glucopyranoside |
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| Synonym | More Synonyms |
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Arbutin BiologicalActivity
| Description | Arbutin(β-Arbutin) is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos; inhibits tyrosinase and thus prevents the formation of melanin.IC50 value:Target: tyrosinase |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>TyrosinaseNatural Products >>PhenolsResearch Areas >>Others |
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| References | [1]. Arbutin, From Wikipedia |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 561.6±50.0 °C at 760 mmHg |
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| Melting Point | 195-198 °C |
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| Molecular Formula | C12H16O7 |
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| Molecular Weight | 272.251 |
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| Flash Point | 293.4±30.1 °C |
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| Exact Mass | 272.089600 |
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| PSA | 119.61000 |
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| LogP | -1.35 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.650 |
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| InChIKey | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
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| SMILES | OCC1OC(Oc2ccc(O)cc2)C(O)C(O)C1O |
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| Water Solubility | 10-15 g/100 mL at 20 ºC |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- CE8863000
- CHEMICAL NAME :
- Arbutin
- CAS REGISTRY NUMBER :
- 497-76-7
- BEILSTEIN REFERENCE NO. :
- 0089673
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C12-H16-O7
- MOLECULAR WEIGHT :
- 272.28
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 13600 mg/kg
- SEX/DURATION :
- female 14 day(s) pre-mating female 20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,282,1988 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1290 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 995 (estimated) No. of Female Employees: 745 (estimated)
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xn |
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| Risk Phrases | R20/21/22 |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | CE8863000 |
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| HS Code | 29389090 |
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Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Ericolin) |
| 4-Hydroxyphenyl β-D-glucopyranoside |
| Uresol |
| Hydroquinone-β-D-glucoside |
| EINECS 207-850-3 |
| Hydroquinone-b-D-glucopyranoside |
| p-Hydroxyphenyl β-D-glucopyranoside |
| Hydroquinone-β-D-glucopyranoside |
| Hydroquinoneβ-D-glucopyranoside |
| hydroquinone O-beta-D-glucopyranoside |
| UVASOL |
| Arbutosie |
| MFCD00016915 |
| P-ARBUTIN |
| β-D-Glucopyranoside, 4-hydroxyphenyl |
| 4-Hydroxyphenyl-β-D-glucopyranosidep |
| 4-Hydroxyphenyl-β-glucopyranoside |
| 4-Hydroxyphenyl Beta-D-Glucopyranoside |
| (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol |
| b-Arbutin |
| Arbutin |
| 4-Hydroxyphenyl-β-D-glucopyranoside |
| hydroquinone O-β-D-glucopyranoside |
| URSIN |
| (2R,3S,4S,5R,6S)-2-(Hydroxyméthyl)-6-(4-hydroxyphénoxy)tétrahydro-2H-pyran-3,4,5-triol |
| 4-Hydroxyphenyl-b-D-glucopyranoside |
| ARBUTOSIDE |
